{"id":"W2936704121","doi":"10.1021/acsomega.9b00008","title":"Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono-, Di-, and Trifluorinated <scp>d</scp>-Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition","year":2019,"lang":"en","type":"article","venue":"ACS Omega","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Division of Molecular and Cellular Biosciences; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Phosphoglucomutase; Glucokinase; Chemistry; Derivatization; Phosphorylation; Biochemistry; Anomer; Stereochemistry; Binding site; Enzyme; Isozyme; Mass spectrometry; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150879,0.0003654431,0.0001309881,0.0001178369,0.0001144082,0.0001148087,0.0002360323,0.0001921958,0.0007794964],"category_scores_gemma":[0.00009327669,0.0001099183,0.0002167579,0.0002221987,0.0001123188,0.0001699888,0.00009323853,0.0003186903,0.0002733696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002282883,"about_ca_system_score_gemma":0.0002479616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154905,"about_ca_topic_score_gemma":0.001537988,"domain_scores_codex":[0.9999372,0.000008058627,0.000004279113,0.00001698495,0.0000137063,0.00001974977],"domain_scores_gemma":[0.9999609,0.000004565376,0.0000108394,0.000005312319,0.000009532391,0.000008862798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001048803,0.00002781708,0.0001141196,0.00003946974,0.000006761531,0.00007427545,0.00001838774,0.0003384616,0.9960058,0.0002722272,0.00004708819,0.00295063],"study_design_scores_gemma":[0.000006966876,0.0001598037,0.0003932329,0.000001900398,0.000006027173,0.00009826777,0.000007145155,0.0003456668,0.9975001,0.0000369189,0.001440073,0.000003669445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658147,0.002017938,0.02558058,0.0001197043,0.0000379217,0.00008502824,0.0009342445,0.0001092352,0.005300764],"genre_scores_gemma":[0.9843247,0.001675345,0.01063539,0.00004680093,0.000006422931,0.0000290776,0.0009886436,0.00003163341,0.002261981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001154905,"threshold_uncertainty_score":0.002607703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00500155286154958,"score_gpt":0.2231157997747333,"score_spread":0.2181142469131837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}