{"id":"W2936704121","doi":"10.1021/acsomega.9b00008","title":"Synthesis, Derivatization, and Structural Analysis of Phosphorylated Mono-, Di-, and Trifluorinated <scp>d</scp>-Gluco-heptuloses by Glucokinase: Tunable Phosphoglucomutase Inhibition","year":2019,"lang":"en","type":"article","venue":"ACS Omega","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Division of Molecular and Cellular Biosciences; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Phosphoglucomutase; Glucokinase; Chemistry; Derivatization; Phosphorylation; Biochemistry; Anomer; Stereochemistry; Binding site; Enzyme; Isozyme; Mass spectrometry; Chromatography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001905337,0.0003306243,0.0008585807,0.0004408258,0.0001059255,0.00006795014,0.00008649853,0.0001769958,0.00007562544],"category_scores_gemma":[0.0007812763,0.0002944637,0.0001305826,0.001484404,0.0001658565,0.0003582113,0.00007561053,0.0001500334,0.000009160303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004009121,"about_ca_system_score_gemma":0.00008013383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002566982,"about_ca_topic_score_gemma":0.000007609682,"domain_scores_codex":[0.9981129,0.00007531408,0.0005207031,0.0005388735,0.0003863267,0.0003659164],"domain_scores_gemma":[0.9983223,0.0003290641,0.0002733617,0.0004510389,0.000285419,0.0003387997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007021452,0.0006195853,0.7272989,0.000840023,0.002971766,0.00007030693,0.00116912,0.0001707064,0.2511837,0.0008224109,0.005992976,0.008158358],"study_design_scores_gemma":[0.003680368,0.0002131472,0.500061,0.0001215172,0.004449943,0.00001360102,0.0009485857,0.003242498,0.4840471,0.0002036836,0.002772504,0.000245982],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871518,0.01133819,0.00003545247,0.00007622167,0.00009148985,0.000530234,0.0003319529,0.0000930442,0.0003516264],"genre_scores_gemma":[0.9968585,0.001270046,0.00009384486,0.0002070583,0.00002714595,0.00002926435,0.000746674,0.00004090147,0.0007265357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2328635,"threshold_uncertainty_score":0.9999508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00500155286154958,"score_gpt":0.2231157997747333,"score_spread":0.2181142469131837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}