{"id":"W2936789044","doi":"10.1186/s12934-019-1111-3","title":"Engineering metabolite-responsive transcriptional factors to sense small molecules in eukaryotes: current state and perspectives","year":2019,"lang":"en","type":"review","venue":"Microbial Cell Factories","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Chinese Academy of Agricultural Sciences; Agricultural Science and Technology Innovation Program; Directorate for Engineering; National Science Foundation","keywords":"Synthetic biology; Biomanufacturing; Computational biology; Biology; Biochemical engineering; Biotechnology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001568892,0.0006476099,0.0005238141,0.0003688805,0.0002368996,0.001499508,0.0006302293,0.001159082,0.001202558],"category_scores_gemma":[0.0005130275,0.0004219882,0.0005531776,0.0005307955,0.0009306087,0.00268259,0.0007041385,0.001163697,0.0007663027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007307885,"about_ca_system_score_gemma":0.0006099087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004256439,"about_ca_topic_score_gemma":0.0005541151,"domain_scores_codex":[0.9997304,0.00004445229,0.0000330572,0.00006310309,0.0000802162,0.0000488137],"domain_scores_gemma":[0.9997236,0.00009929013,0.00005735024,0.00002614992,0.00005221236,0.00004138966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005088316,0.0004292495,0.00221886,0.007888909,0.00009229614,0.0006281101,0.0007227184,0.004888315,0.4349495,0.06234015,0.005147466,0.4801857],"study_design_scores_gemma":[0.00007934803,0.001982346,0.002974231,0.001039018,0.0001763162,0.001070668,0.0007935821,0.01003993,0.2615055,0.0289386,0.6912509,0.0001496676],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04380195,0.8749678,0.06655813,0.004273674,0.0004078859,0.00009223072,0.0002047354,0.0003131662,0.009380437],"genre_scores_gemma":[0.1182232,0.8124301,0.06296685,0.001290393,0.0003458491,0.0001428979,0.0004240758,0.00007194134,0.004104702],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001568892,"threshold_uncertainty_score":0.008297205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03568521291902533,"score_gpt":0.2794112523010129,"score_spread":0.2437260393819876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}