{"id":"W2936850520","doi":"10.1101/613794","title":"Modeling implicates inhibitory network bistability as an underpinning of seizure initiation","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neural dynamics and brain function","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Inhibitory postsynaptic potential; Neuroscience; GABAergic; Bistability; Excitatory postsynaptic potential; Nerve net; Network dynamics; Mechanism (biology); Epilepsy; Interneuron; Biology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000986906,0.0002465359,0.0001830078,0.0001933151,0.0001675062,0.0003709726,0.000495459,0.000385181,0.001610486],"category_scores_gemma":[0.0004463402,0.0001263556,0.0002509354,0.00009423446,0.0003806454,0.0003632045,0.0003781478,0.0003210451,0.0001138184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004023352,"about_ca_system_score_gemma":0.0003585962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004010861,"about_ca_topic_score_gemma":0.003231137,"domain_scores_codex":[0.9999621,0.000007284079,0.000001789477,0.000008334458,0.000009801846,0.00001073715],"domain_scores_gemma":[0.9998668,0.00004590908,0.00004312603,0.0000103777,0.00001444474,0.00001924807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003519969,0.00001950738,0.003657168,0.0000402395,0.00002302023,0.000237487,0.0000417952,0.958895,0.02559929,0.008908694,0.0002209088,0.002321727],"study_design_scores_gemma":[0.000003164088,0.00001202254,0.0006434071,0.00000312806,0.000004973049,0.00002155358,0.000009083717,0.9960795,0.001046484,0.002002682,0.0001711582,0.000002789178],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8207132,0.0004826847,0.1577927,0.0004922522,0.00004954054,0.00003473603,0.0002165682,0.0002658623,0.01995265],"genre_scores_gemma":[0.9977652,0.00009835709,0.001520286,0.00001437496,0.000004204583,0.000009991966,0.00002339811,0.000009475535,0.0005548758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004010861,"threshold_uncertainty_score":0.007975042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03105599331878348,"score_gpt":0.2481868564412355,"score_spread":0.217130863122452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}