{"id":"W2936913202","doi":"10.1182/bloodadvances.2018030577","title":"Targeting CD47 in Sézary syndrome with SIRPαFc","year":2019,"lang":"en","type":"article","venue":"Blood Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"National Cancer Institute","keywords":"CD47; Phagocytosis; Lymphoma; Decoy; Medicine; Cutaneous T-cell lymphoma; Cancer research; Immunology; Receptor; Internal medicine; Mycosis fungoides","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002082273,0.0001249973,0.0002883607,0.0001257017,0.00002474342,0.00001344261,0.0001060902,0.00004492736,0.00180013],"category_scores_gemma":[0.00003661456,0.00009355202,0.00003648358,0.0003052171,0.00005239189,0.0001772902,0.00003641786,0.0002571596,0.0001579149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002942664,"about_ca_system_score_gemma":0.00007496431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002800582,"about_ca_topic_score_gemma":0.00002296256,"domain_scores_codex":[0.9988027,0.00003261443,0.0001679788,0.0002904294,0.0003606237,0.000345625],"domain_scores_gemma":[0.9994702,0.00009815252,0.00004281261,0.0002591063,0.00004252974,0.00008717263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007963908,0.0005137779,0.7847587,0.0004666513,0.0001256777,0.002489322,0.0003303987,0.000275651,0.1970533,0.00008257122,0.00007007222,0.01303751],"study_design_scores_gemma":[0.04285132,0.01292728,0.4177577,0.003633959,0.0002955827,0.007354936,0.0043182,0.0008918782,0.1159979,0.00104379,0.39086,0.00206738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794697,0.004311919,0.000006870401,0.0002746273,0.00007405648,0.0005062772,0.000002155109,0.000051731,0.01530272],"genre_scores_gemma":[0.9867179,0.0004171857,0.00138655,0.0001505787,0.00007747352,0.00002653546,0.00001165631,0.00003207212,0.01118007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3907899,"threshold_uncertainty_score":0.9991124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009672638446286328,"score_gpt":0.2801466938646356,"score_spread":0.2704740554183492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}