{"id":"W2936958253","doi":"10.1371/journal.pone.0215170","title":"A carnosine analog with therapeutic potentials in the treatment of disorders related to oxidative stress","year":2019,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Biochemical effects in animals","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"","keywords":"Carnosine; Oxidative stress; Anserine; Skeletal muscle; Reactive oxygen species; Oxidative phosphorylation; Antioxidant; Biochemistry; Inflammation; Mitochondrion; Chemistry; Cell biology; Biology; Endocrinology; Histidine; Immunology; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137974,0.0002478137,0.0002509565,0.0003212126,0.0001477896,0.0001409515,0.0002307827,0.0003485273,0.001009442],"category_scores_gemma":[0.0000620666,0.00006485526,0.0001982205,0.0001900118,0.0001440839,0.0001826146,0.0002113743,0.0004996724,0.0001235972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001391942,"about_ca_system_score_gemma":0.0001949757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004998573,"about_ca_topic_score_gemma":0.001974215,"domain_scores_codex":[0.9999596,0.00001033028,0.000004964433,0.0000107179,0.000007907641,0.000006518185],"domain_scores_gemma":[0.99997,0.000004270032,0.000009491946,0.000002191305,0.000006352628,0.000007754344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002410925,0.0005448503,0.000514664,0.001672196,0.0001038408,0.0006018696,0.00006552441,0.0003125655,0.9261273,0.0004994759,0.0004846221,0.06666216],"study_design_scores_gemma":[0.001196111,0.02795161,0.01758079,0.0005183376,0.0007328914,0.004189294,0.0002350966,0.001526295,0.8223161,0.0008001403,0.1228758,0.00007753691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6878533,0.3020601,0.004413051,0.0007708026,0.0002885674,0.0001317963,0.0004504865,0.00008505509,0.003946727],"genre_scores_gemma":[0.9141765,0.07655143,0.005598733,0.0003492828,0.00008675908,0.00007460137,0.0004382087,0.000009680923,0.002714756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009442,"threshold_uncertainty_score":0.003376901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02051790000925109,"score_gpt":0.2596637949083026,"score_spread":0.2391458948990515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}