{"id":"W2936978084","doi":"10.1182/blood.v130.suppl_1.2194.2194","title":"Results Update from the DRIVE PK Study: Effects of AG-348, a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pyruvate kinase deficiency; Pyruvate kinase; Medicine; Tolerability; Pharmacokinetics; Pharmacodynamics; Ex vivo; Internal medicine; Anemia; Hemolytic anemia; Pharmacology; Hemoglobin; Adverse effect; Endocrinology; Gastroenterology; Glycolysis; Chemistry; Biochemistry; In vitro; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005765949,0.0009512546,0.003137764,0.0007856847,0.0004535669,0.002635518,0.001059126,0.001927064,0.01472093],"category_scores_gemma":[0.01250652,0.0004662286,0.003923638,0.001417514,0.000383845,0.00152882,0.0008167622,0.002805408,0.002584351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009976707,"about_ca_system_score_gemma":0.001392542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001012123,"about_ca_topic_score_gemma":0.002805371,"domain_scores_codex":[0.9962113,0.001811433,0.000739319,0.0002992556,0.0007297071,0.0002090251],"domain_scores_gemma":[0.9872053,0.005735552,0.003012661,0.0007008919,0.002560553,0.0007849992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3670981,0.002729509,0.02227355,0.02551589,0.02120679,0.0005358341,0.0003729264,0.001157682,0.006257311,0.001623998,0.2061761,0.3450524],"study_design_scores_gemma":[0.3858002,0.04723798,0.1127507,0.007987922,0.03987163,0.001783091,0.0003479075,0.0008784938,0.003709279,0.003061393,0.3962786,0.0002927555],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.283895,0.3037129,0.006000285,0.04131797,0.008976168,0.01256468,0.2486067,0.0008626453,0.09406369],"genre_scores_gemma":[0.618095,0.1030971,0.01305077,0.0551776,0.009217324,0.01637829,0.1671658,0.0005611437,0.01725704],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01472093,"threshold_uncertainty_score":0.04924637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009270670414417717,"score_gpt":0.2377377369287966,"score_spread":0.2284670665143789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}