{"id":"W2936978084","doi":"10.1182/blood.v130.suppl_1.2194.2194","title":"Results Update from the DRIVE PK Study: Effects of AG-348, a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Pyruvate kinase deficiency; Pyruvate kinase; Medicine; Tolerability; Pharmacokinetics; Pharmacodynamics; Ex vivo; Internal medicine; Anemia; Hemolytic anemia; Pharmacology; Hemoglobin; Adverse effect; Endocrinology; Gastroenterology; Glycolysis; Chemistry; Biochemistry; In vitro; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001830937,0.0002502917,0.0004839347,0.00008274845,0.0002385554,0.00002625167,0.0003021297,0.0001064121,0.00002045934],"category_scores_gemma":[0.0006748855,0.0001534588,0.00007444235,0.0001615172,0.0002085263,0.0001278821,0.0001528475,0.0003228834,0.00003984087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002608491,"about_ca_system_score_gemma":0.00009146662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008074605,"about_ca_topic_score_gemma":0.0002378563,"domain_scores_codex":[0.9983132,0.0001698737,0.000364494,0.0004924645,0.0003409127,0.0003190308],"domain_scores_gemma":[0.9977795,0.0002544754,0.0004230774,0.001279273,0.0001512785,0.0001123914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006080642,0.008934732,0.9443712,0.000106707,0.0002647933,0.0003479288,0.002849962,0.000005590315,0.03418067,0.00004629222,0.0004051823,0.00240634],"study_design_scores_gemma":[0.0282506,0.002967155,0.9419816,0.0002952021,0.0002917736,6.747199e-7,0.0002360132,0.00000630209,0.02550665,0.00006236992,0.0002327757,0.0001689119],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975437,0.00009239173,0.000004084485,0.0002468227,0.0003274427,0.00119064,0.00007130243,0.00003678056,0.0004868523],"genre_scores_gemma":[0.9992328,0.00002993671,0.00008926896,0.000322764,0.0001018403,0.0000496479,0.00007872922,0.00002898043,0.00006597704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02216995,"threshold_uncertainty_score":0.6257869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009270670414417717,"score_gpt":0.2377377369287966,"score_spread":0.2284670665143789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}