{"id":"W2937126128","doi":"10.1016/j.celrep.2019.02.041","title":"Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":140,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Canadian Institute for Advanced Research; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Biology; CRISPR; Gene; Computational biology; Context (archaeology); Genetics; Genome; Stem cell; Cellular differentiation; Regenerative medicine; Embryonic stem cell; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590826,0.0001663921,0.0001680644,0.00003063758,0.00006585744,0.00005386823,0.00006903096,0.0001166401,0.00001794016],"category_scores_gemma":[0.000002810968,0.0001630471,0.00009066474,0.00002475327,0.0000268437,0.000004384114,0.00007746564,0.00004343827,0.000003398314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006257448,"about_ca_system_score_gemma":0.00003450153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008904331,"about_ca_topic_score_gemma":0.000006505458,"domain_scores_codex":[0.9989272,0.00001205172,0.0002907002,0.0004303155,0.0001079524,0.0002317514],"domain_scores_gemma":[0.9993911,0.000005188813,0.0001315313,0.0003290091,0.00006735748,0.00007580649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001659086,0.00002097487,0.003096835,0.0001276922,0.00002717281,0.00002642697,0.00002854345,0.0001225479,0.9961878,0.000002760462,0.00006301044,0.0002796554],"study_design_scores_gemma":[0.0003119287,0.00009098058,0.004480083,0.000008984769,0.0000313739,0.00007717427,0.00005547506,0.00003694868,0.9909995,0.00002119518,0.003680153,0.0002061696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946158,0.001578414,0.002615663,0.000007141689,0.0005377811,0.0005003653,0.00001225941,0.00001751422,0.0001150683],"genre_scores_gemma":[0.995308,0.0001775246,0.0004831824,0.00001424121,0.0001870508,0.00004317082,0.0001192673,0.00003059638,0.003636947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005188257,"threshold_uncertainty_score":0.664887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008317772701550378,"score_gpt":0.2620412780381269,"score_spread":0.2537235053365766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}