{"id":"W2937210610","doi":"10.1007/5584_2019_374","title":"Direct Lineage Reprogramming in the CNS","year":2019,"lang":"en","type":"review","venue":"Advances in experimental medicine and biology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Reprogramming; Induced pluripotent stem cell; Biology; Lineage (genetic); Cell type; Population; Neuroscience; Cell; Cell biology; Embryonic stem cell; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007929119,0.001006183,0.001169881,0.001501863,0.0002166467,0.001136108,0.001042265,0.001113461,0.002841149],"category_scores_gemma":[0.000572459,0.0002865949,0.0002999573,0.001426886,0.0007954065,0.001249655,0.0009857805,0.002025847,0.0020051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008293983,"about_ca_system_score_gemma":0.0008373297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000955751,"about_ca_topic_score_gemma":0.002130253,"domain_scores_codex":[0.9998605,0.00002082059,0.00001669396,0.00003051694,0.00005163132,0.00001982608],"domain_scores_gemma":[0.999819,0.0000965484,0.00002169566,0.000009134356,0.00002889312,0.00002482606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009514802,0.00005423072,0.00008695276,0.007709677,0.00004732853,0.000236217,0.00002651866,0.000499872,0.003671862,0.01205909,0.02781816,0.947695],"study_design_scores_gemma":[0.00002170043,0.00004699652,0.0003420865,0.001628946,0.00005200229,0.0005646226,0.00002358437,0.00008989202,0.001468976,0.003905754,0.9918413,0.00001429035],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001139486,0.9973674,0.0003039567,0.0003021017,0.0004067078,0.000003362232,0.00001931295,0.00001098792,0.001472265],"genre_scores_gemma":[0.0006937757,0.997463,0.0002651366,0.0002863192,0.0002123726,0.000005811481,0.00002810512,0.000002700469,0.001042664],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002841149,"threshold_uncertainty_score":0.009504557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07612313583034881,"score_gpt":0.4461931613523011,"score_spread":0.3700700255219523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}