{"id":"W2937236090","doi":"10.3390/ijms20081810","title":"miR-590-3p Targets Cyclin G2 and FOXO3 to Promote Ovarian Cancer Cell Proliferation, Invasion, and Spheroid Formation","year":2019,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Canadian Institutes of Health Research; York University","keywords":"FOXO3; microRNA; Gene silencing; Transfection; Cancer research; Biology; Cell biology; Ovarian cancer; Cell growth; Cancer; Cell culture; Signal transduction; Gene; Genetics; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003534479,0.00009656067,0.00009415242,0.00008788628,0.00005477625,0.00012215,0.0002191109,0.00005812425,0.00004863276],"category_scores_gemma":[0.0000406634,0.00008304918,0.00004067225,0.00007371856,0.00005848203,0.00008304224,0.00005180127,0.00005402958,0.000004238573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002778017,"about_ca_system_score_gemma":0.00009227692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002604256,"about_ca_topic_score_gemma":0.00006389037,"domain_scores_codex":[0.9989466,0.00004302506,0.000287116,0.000191916,0.000423264,0.0001080693],"domain_scores_gemma":[0.9992658,0.000005427217,0.0001983751,0.00007133564,0.0003715281,0.00008755623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006363547,0.00002697175,0.004193837,0.000008968655,0.00002393883,0.000002810719,0.0002809965,0.000802233,0.9914362,0.0001517036,0.000213028,0.00279561],"study_design_scores_gemma":[0.001039287,0.0005882666,0.01747418,0.00007235079,0.00001630345,0.0001292611,0.0001906514,0.00109404,0.9692749,0.0005007645,0.009426723,0.0001932299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862592,0.001058871,0.01012363,0.001718756,0.0003892585,0.0001927955,0.000007710086,0.000003174364,0.0002465895],"genre_scores_gemma":[0.9944804,0.0001487987,0.004668425,0.0004771507,0.00009408767,0.000004373824,0.00001042884,0.000006774444,0.0001096137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02216132,"threshold_uncertainty_score":0.3386647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009319413955146731,"score_gpt":0.2590673610939227,"score_spread":0.249747947138776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}