{"id":"W2937277570","doi":"10.1016/j.dadm.2019.01.011","title":"Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of British Columbia; Hotchkiss Brain Institute; University of Toronto; Canadian Sport Centre Pacific; Centre for Addiction and Mental Health; Alberta Children's Hospital; Mental Health Research Canada; University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; Leibniz-Gemeinschaft; National Institutes of Health; Janssen Pharmaceuticals; Dementias Platform UK; Novo Nordisk Fonden; Sanofi Genzyme; Horizon 2020 Framework Programme; Fondation pour la Recherche Médicale; Deutsche Forschungsgemeinschaft; H. Lundbeck A/S; Fondation Neurodis; Canadian Institutes of Health Research; Prothena; Eli Lilly and Company; Lundbeckfonden; EU Joint Programme – Neurodegenerative Disease Research; Novartis Pharma; AbbVie; Association France Parkinson; Agence Nationale de la Recherche; Wellcome Trust; National Health and Medical Research Council; International Parkinson and Movement Disorder Society; Biogen; Bristol-Myers Squibb; Chiesi Farmaceutici; Sanofi; Austrian Science Fund; UCB Pharma; Michael J. Fox Foundation for Parkinson's Research; AOP Orphan; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Medical Research Council; Damp Stiftung; Teva Pharmaceutical Industries; U.S. Department of Veterans Affairs","keywords":"Neuroimaging; Biomarker; Imaging biomarker; Medicine; Clinical trial; Neuroscience; Psychology; Psychiatry; Internal medicine; Magnetic resonance imaging; Radiology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00475276,0.0007559397,0.001714717,0.0004260099,0.0003020417,0.0002863034,0.0003502168,0.000164769,0.00005568124],"category_scores_gemma":[0.0007180836,0.0007020892,0.00151519,0.0004113677,0.0000991093,0.0006053539,0.0002142073,0.000300031,0.00002125211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001852165,"about_ca_system_score_gemma":0.0007571101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000747611,"about_ca_topic_score_gemma":0.000006299459,"domain_scores_codex":[0.9926708,0.001227836,0.002237196,0.001883555,0.0007834917,0.00119713],"domain_scores_gemma":[0.9946826,0.002399838,0.0007239907,0.0009961947,0.000198342,0.0009990223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002653913,0.002785733,0.8908875,0.0004833585,0.006303287,0.00007873249,0.00001812229,0.000005454473,0.0002015296,0.000218286,0.0004794593,0.09588464],"study_design_scores_gemma":[0.0114206,0.0004050696,0.9448991,0.0009247799,0.0152477,0.000002742763,0.0002403939,0.01635398,0.0004920592,0.0002568193,0.009156697,0.0006000302],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9468732,0.02304773,0.003894937,0.003375333,0.005313904,0.01642443,0.0005531108,0.0004022299,0.000115094],"genre_scores_gemma":[0.9802161,0.0007349207,0.01062347,0.0001869437,0.0004949039,0.007293918,0.000278173,0.0001672157,0.000004363427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09528461,"threshold_uncertainty_score":0.999543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1295756510867078,"score_gpt":0.435461703887719,"score_spread":0.3058860528010112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}