{"id":"W2937277570","doi":"10.1016/j.dadm.2019.01.011","title":"Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of British Columbia; Hotchkiss Brain Institute; University of Toronto; Canadian Sport Centre Pacific; Centre for Addiction and Mental Health; Alberta Children's Hospital; Mental Health Research Canada; University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; Leibniz-Gemeinschaft; National Institutes of Health; Janssen Pharmaceuticals; Dementias Platform UK; Novo Nordisk Fonden; Sanofi Genzyme; Horizon 2020 Framework Programme; Fondation pour la Recherche Médicale; Deutsche Forschungsgemeinschaft; H. Lundbeck A/S; Fondation Neurodis; Canadian Institutes of Health Research; Prothena; Eli Lilly and Company; Lundbeckfonden; EU Joint Programme – Neurodegenerative Disease Research; Novartis Pharma; AbbVie; Association France Parkinson; Agence Nationale de la Recherche; Wellcome Trust; National Health and Medical Research Council; International Parkinson and Movement Disorder Society; Biogen; Bristol-Myers Squibb; Chiesi Farmaceutici; Sanofi; Austrian Science Fund; UCB Pharma; Michael J. Fox Foundation for Parkinson's Research; AOP Orphan; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Medical Research Council; Damp Stiftung; Teva Pharmaceutical Industries; U.S. Department of Veterans Affairs","keywords":"Neuroimaging; Biomarker; Imaging biomarker; Medicine; Clinical trial; Neuroscience; Psychology; Psychiatry; Internal medicine; Magnetic resonance imaging; Radiology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.144353,0.00349553,0.003684363,0.01333966,0.004284854,0.01611294,0.007279588,0.008214579,0.003726061],"category_scores_gemma":[0.1794397,0.001613166,0.006046009,0.005388548,0.02207507,0.01783149,0.01188578,0.01081505,0.002501468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01151271,"about_ca_system_score_gemma":0.01639799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002820692,"about_ca_topic_score_gemma":0.002437477,"domain_scores_codex":[0.9021983,0.05831377,0.01703513,0.006266018,0.0135609,0.002625863],"domain_scores_gemma":[0.8453276,0.08589796,0.01380178,0.009001811,0.04118939,0.004781464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0003843271,0.0002434582,0.01072947,0.002662808,0.0004623895,0.0003588037,0.002654857,0.005128575,0.001121518,0.7892453,0.0178103,0.1691982],"study_design_scores_gemma":[0.0003309333,0.001307992,0.007609664,0.004585594,0.0009781303,0.001206695,0.001793108,0.03278069,0.001804292,0.8811969,0.0660651,0.0003407866],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01529634,0.01912346,0.8384243,0.09591208,0.002918391,0.002850813,0.000769648,0.001186463,0.02351851],"genre_scores_gemma":[0.1967125,0.003374656,0.7813575,0.01079254,0.00184969,0.003453956,0.0006824164,0.0002174077,0.001559373],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.144353,"threshold_uncertainty_score":0.7634205,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1295756510867078,"score_gpt":0.435461703887719,"score_spread":0.3058860528010112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}