{"id":"W2937319110","doi":"10.1002/mds.27659","title":"Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms","year":2019,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":374,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Genentech; H. Lundbeck A/S; National Cancer Institute; Servier; Bundesministerium für Bildung und Forschung; University of Glasgow; Parkinson's UK; Multiple System Atrophy Coalition; Institute of Genetics; Barts Charity; Canada First Research Excellence Fund; Bristol-Myers Squibb; American Parkinson Disease Association; Consortium canadien en neurodégénérescence associée au vieillissement; EU Joint Programme – Neurodegenerative Disease Research; University College London; Wellcome Trust; Deutsche Forschungsgemeinschaft; McGill University; Helsingin Yliopisto; U.S. Department of Defense; Eli Lilly and Company; Itä-Suomen Yliopisto; Michael J. Fox Foundation for Parkinson's Research; National Institute on Aging; National Institute for Health and Care Research; Medical Research Council; Teva Pharmaceutical Industries; Pfizer; Biogen; Helsingin ja Uudenmaan Sairaanhoitopiiri; GlaxoSmithKline; U.S. Department of Health and Human Services; National Institutes of Health; Rosetrees Trust","keywords":"Genome-wide association study; Genetic association; Heritability; Age of onset; Missing heritability problem; Genetics; Biology; Disease; Allele; Bonferroni correction; Parkinson's disease; Genetic variation; Medicine; Genotype; Single-nucleotide polymorphism; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002980664,0.0003484779,0.0004352772,0.0001148155,0.000200765,0.00006450783,0.0001057535,0.00008404175,0.0006396401],"category_scores_gemma":[0.00010078,0.000338228,0.0001526762,0.000159912,0.00002700423,0.00008904631,0.0002182926,0.0001187061,0.0002259492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007687214,"about_ca_system_score_gemma":0.00006805865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001799933,"about_ca_topic_score_gemma":0.0003779285,"domain_scores_codex":[0.9975826,0.0001239464,0.0003380519,0.0007576405,0.0006737485,0.0005239722],"domain_scores_gemma":[0.9987541,0.00009831748,0.000171719,0.0005169777,0.00004202255,0.0004168886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003023285,0.001436332,0.9953051,0.00009065576,0.0003783398,0.0001097976,0.000329893,0.00002516193,0.0002859318,0.00009045481,0.0003129808,0.001333013],"study_design_scores_gemma":[0.004601969,0.0007089718,0.9757366,0.00002929758,0.0004508349,2.00469e-7,0.0007760553,0.0001819117,0.000044157,0.01159593,0.005566899,0.00030723],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947414,0.0008144004,0.0001357707,0.001194657,0.0001473869,0.002147128,0.0001076522,0.0001092687,0.0006023118],"genre_scores_gemma":[0.9937735,0.0002162022,0.0006077234,0.003417522,0.00001411134,0.0002215408,0.0001890085,0.00006342732,0.001496985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01956857,"threshold_uncertainty_score":0.999907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007688148052080976,"score_gpt":0.2285716296199257,"score_spread":0.2208834815678447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}