{"id":"W2937319110","doi":"10.1002/mds.27659","title":"Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms","year":2019,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":374,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Genentech; H. Lundbeck A/S; National Cancer Institute; Servier; Bundesministerium für Bildung und Forschung; University of Glasgow; Parkinson's UK; Multiple System Atrophy Coalition; Institute of Genetics; Barts Charity; Canada First Research Excellence Fund; Bristol-Myers Squibb; American Parkinson Disease Association; Consortium canadien en neurodégénérescence associée au vieillissement; EU Joint Programme – Neurodegenerative Disease Research; University College London; Wellcome Trust; Deutsche Forschungsgemeinschaft; McGill University; Helsingin Yliopisto; U.S. Department of Defense; Eli Lilly and Company; Itä-Suomen Yliopisto; Michael J. Fox Foundation for Parkinson's Research; National Institute on Aging; National Institute for Health and Care Research; Medical Research Council; Teva Pharmaceutical Industries; Pfizer; Biogen; Helsingin ja Uudenmaan Sairaanhoitopiiri; GlaxoSmithKline; U.S. Department of Health and Human Services; National Institutes of Health; Rosetrees Trust","keywords":"Genome-wide association study; Genetic association; Heritability; Age of onset; Missing heritability problem; Genetics; Biology; Disease; Allele; Bonferroni correction; Parkinson's disease; Genetic variation; Medicine; Genotype; Single-nucleotide polymorphism; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004157886,0.0005268104,0.0007362774,0.001418362,0.0005492702,0.0009107548,0.0004984746,0.0005567757,0.001265721],"category_scores_gemma":[0.00523256,0.0002698916,0.001049961,0.001738749,0.000439272,0.0003349897,0.001008668,0.0007026317,0.0001659157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002070084,"about_ca_system_score_gemma":0.0003471247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004558281,"about_ca_topic_score_gemma":0.006275758,"domain_scores_codex":[0.9984363,0.0006112949,0.0001395369,0.0005260972,0.0001978139,0.00008897168],"domain_scores_gemma":[0.9958894,0.002089062,0.0006717455,0.0007343216,0.0003689972,0.0002465183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002284722,0.00003976788,0.9835365,0.000100848,0.002076808,0.0003486417,0.0002567706,0.0004843709,0.002763934,0.0001279618,0.0003566334,0.009679335],"study_design_scores_gemma":[0.00002010268,0.00005795325,0.9972503,0.00002198292,0.0007836162,0.0003776238,0.000071697,0.0003191258,0.0002869152,0.0001773489,0.0006262339,0.000007075296],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881032,0.004637143,0.00477948,0.0001560149,0.00002981934,0.00004068515,0.001328664,0.00004544708,0.0008795854],"genre_scores_gemma":[0.9947582,0.001075387,0.002393387,0.00008221626,0.00003840408,0.00003411058,0.001444535,0.00001874218,0.0001549677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004558281,"threshold_uncertainty_score":0.02198929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007688148052080976,"score_gpt":0.2285716296199257,"score_spread":0.2208834815678447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}