{"id":"W2937428609","doi":"10.1038/s41589-019-0270-1","title":"Chemogenetics defines receptor-mediated functions of short chain free fatty acids","year":2019,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council","keywords":"G protein-coupled receptor; Receptor; Free fatty acid receptor 1; Lipolysis; Enteroendocrine cell; Cell biology; Fatty acid; Biology; Biochemistry; Chemistry; Adipose tissue; Endocrine system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0001335109,0.000222166,0.0003093002,0.00004035314,0.00002781279,0.000005700384,0.0004025171,0.001352847,0.0003508477],"category_scores_gemma":[0.0003261292,0.0001905569,0.0001700244,0.0001582035,0.0001135613,0.000002246644,0.00022445,0.0003946863,0.0000289245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001195545,"about_ca_system_score_gemma":0.00005159358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003032291,"about_ca_topic_score_gemma":0.000001499539,"domain_scores_codex":[0.9987398,0.00004280441,0.0003029715,0.0004866515,0.0001104768,0.0003172674],"domain_scores_gemma":[0.9991105,0.00004588317,0.00008420274,0.000531196,0.0001313345,0.00009689335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009165404,0.0000500488,0.009865135,0.00001937417,0.00006729301,2.132769e-7,0.000006813391,0.000003437442,0.9874938,0.0003368034,0.001190398,0.0008750787],"study_design_scores_gemma":[0.0004395081,0.0002241622,0.0002140233,0.000009934298,0.00001364752,0.000005642612,0.00002334946,0.00002119639,0.9666442,0.0001816481,0.03200817,0.0002145369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947338,0.002135586,0.0006215964,0.0001636749,0.0006955253,0.0001918954,0.0001669706,0.00002381512,0.001267158],"genre_scores_gemma":[0.9947453,0.0002260358,0.002583128,0.0003514144,0.0003668906,0.00001563176,0.001518353,0.00002783748,0.0001654105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03081778,"threshold_uncertainty_score":0.9999436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005922165671802555,"score_gpt":0.2294124426070625,"score_spread":0.2234902769352599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}