{"id":"W2937568612","doi":"10.1172/jci.insight.127527","title":"Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8-deficient patients","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Medical Research Council; National Cancer Institute; National Institutes of Health; New South Wales Government; Australian Government; Office of Health and Medical Research; Jeffrey Modell Foundation; Howard Hughes Medical Institute","keywords":"Immunology; Immune system; Hematopoietic stem cell transplantation; Lymphocyte; Immunodeficiency; Primary immunodeficiency; Haematopoiesis; Medicine; Stem cell; Biology; Transplantation; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001093923,0.0002893658,0.0002949886,0.0002219209,0.0001230875,0.0002659365,0.0001860699,0.0001816599,0.001092001],"category_scores_gemma":[0.0001519788,0.0000669298,0.000153918,0.0001029593,0.0001775133,0.00009611579,0.0001828451,0.0004281192,0.0002632453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001179648,"about_ca_system_score_gemma":0.00009556024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001483569,"about_ca_topic_score_gemma":0.000190708,"domain_scores_codex":[0.9999577,0.00000902888,0.000005292257,0.000007372152,0.00001031607,0.00001026679],"domain_scores_gemma":[0.999934,0.00001053896,0.00001289592,0.000008691051,0.000004366573,0.00002951641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005180825,0.0008901755,0.02135426,0.000248311,0.0001099371,0.007713645,0.00021864,0.001030817,0.821463,0.0005990504,0.002384274,0.138807],"study_design_scores_gemma":[0.002778954,0.02295893,0.3146983,0.0001841042,0.0005539971,0.07802025,0.0005388968,0.01043128,0.5332289,0.001830539,0.03471829,0.00005760324],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954641,0.001142776,0.001146663,0.0001222064,0.00002205876,0.00003512603,0.0001571477,0.0002051951,0.00170466],"genre_scores_gemma":[0.9986331,0.0002567901,0.0004320721,0.00006672585,0.000009249758,0.000013116,0.0002067008,0.00001140881,0.0003707232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092001,"threshold_uncertainty_score":0.003653049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004312763127116749,"score_gpt":0.174967908468025,"score_spread":0.1706551453409083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}