{"id":"W2937737908","doi":"10.1158/0008-5472.can-18-3631","title":"Exploiting DNA Replication Stress for Cancer Treatment","year":2019,"lang":"en","type":"review","venue":"Cancer Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":251,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Replication (statistics); DNA replication; Biology; Computational biology; DNA; Genetics; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005590538,0.0003022047,0.0006606732,0.0001241528,0.0001343461,0.00005394998,0.0004790878,0.0003899195,0.0000700261],"category_scores_gemma":[0.0001329902,0.0002492481,0.0003811583,0.0001839692,0.00005567525,0.000003344752,0.0001900642,0.0001910744,0.00003498803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005951721,"about_ca_system_score_gemma":0.001436875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002071755,"about_ca_topic_score_gemma":0.0001545769,"domain_scores_codex":[0.9974722,0.0002040899,0.0003276547,0.001122533,0.0002904063,0.0005831638],"domain_scores_gemma":[0.9979353,0.00008007611,0.0001725282,0.001376266,0.0003218802,0.0001139754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002391869,0.00004011313,0.000002902633,0.006576491,0.0002315946,9.311911e-7,0.00001852422,0.000003035004,0.008287438,0.00007364061,0.002066879,0.9826745],"study_design_scores_gemma":[0.0002307132,0.0002887548,2.471974e-7,0.002716384,0.0001393846,0.00000188021,0.00002531561,0.000004002941,0.05597333,0.00001786674,0.940366,0.0002360949],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00065446,0.9947651,0.00007338323,0.00004924319,0.0003040448,0.003000617,0.0008336839,0.00001980399,0.0002996504],"genre_scores_gemma":[0.00006349028,0.9700823,0.0001174809,0.00001582961,0.001200482,0.01508268,0.001022616,0.0001242966,0.01229079],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9824384,"threshold_uncertainty_score":0.9999959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.269096033623929,"score_gpt":0.5108488175910731,"score_spread":0.2417527839671442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}