{"id":"W2937806070","doi":"10.1093/schbul/sbz022.085","title":"21.1 ADULT RESCUE OF NMDA RECEPTORS IMPROVES COGNITION AND ASTROCYTIC GENE EXPRESSION PATTERNS","year":2019,"lang":"en","type":"article","venue":"Schizophrenia Bulletin","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Gene knockdown; NMDA receptor; Biology; In situ hybridization; Endocrinology; Molecular biology; Internal medicine; Gene expression; Receptor; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004415054,0.001298363,0.001297308,0.001103444,0.0004049927,0.0006488826,0.000816353,0.0009593313,0.007285152],"category_scores_gemma":[0.0002699418,0.0004561611,0.0008325046,0.0003321204,0.0007095382,0.0005236891,0.0007153425,0.002274367,0.003506676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005391376,"about_ca_system_score_gemma":0.0008869924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001978829,"about_ca_topic_score_gemma":0.003487159,"domain_scores_codex":[0.9993104,0.00005268657,0.0001001831,0.000151106,0.0002117086,0.0001739127],"domain_scores_gemma":[0.9992931,0.0000413495,0.0001579037,0.00006411688,0.0001083632,0.0003350037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005671008,0.0002573865,0.000152309,0.000128275,0.00002271925,0.0001915613,0.00007391399,0.0000722201,0.9929839,0.0002565372,0.0007963785,0.004497617],"study_design_scores_gemma":[0.0002398593,0.00271913,0.008452917,0.00008164951,0.0001048167,0.0007854609,0.0001564629,0.0007712089,0.9618757,0.0003309223,0.02444907,0.00003270127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515939,0.005472476,0.009943178,0.001248325,0.0006184643,0.0003903084,0.01228305,0.002932674,0.01551759],"genre_scores_gemma":[0.8708211,0.006081954,0.0171472,0.0009401602,0.000138558,0.001126779,0.01454369,0.00138135,0.08781917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007285152,"threshold_uncertainty_score":0.02437127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00383085339192829,"score_gpt":0.1926554676093358,"score_spread":0.1888246142174075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}