{"id":"W2937808345","doi":"10.1016/j.jid.2019.03.610","title":"534 Effects on CD3, Treg and TH17 cell numbers in skin biopsies after 16-week mirikizumab treatment, evaluated by an epigenetic assay","year":2019,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Medicine; Interleukin 17; Psoriasis; Psoriasis Area and Severity Index; Placebo; CD3; Internal medicine; Immunology; Gastroenterology; Cytokine; Pathology; Immune system; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00027414,0.0002602576,0.0004078786,0.0002219488,0.0002388057,0.0002951245,0.00009985764,0.0003261555,0.002334347],"category_scores_gemma":[0.0001508535,0.0001818422,0.0003840449,0.0001851814,0.0002671836,0.000202874,0.0001197432,0.000935213,0.0003799869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001231127,"about_ca_system_score_gemma":0.0001323213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003281654,"about_ca_topic_score_gemma":0.0009305488,"domain_scores_codex":[0.9997162,0.00004682216,0.00002714268,0.00006315167,0.00006784393,0.0000787758],"domain_scores_gemma":[0.9999121,0.00001749372,0.00002225752,0.000009873125,0.0000173384,0.00002094159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001998111,0.0001472861,0.001456705,0.000054186,0.00001636599,0.0000277258,0.0000597829,0.00003930406,0.9918345,0.00001997938,0.00003920415,0.004306822],"study_design_scores_gemma":[0.0001885442,0.005183268,0.08061324,0.00001942916,0.0002173208,0.0002266035,0.0003179911,0.0009374048,0.9094617,0.0001174035,0.002692168,0.00002492307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996449,0.001189537,0.0008014679,0.00005337972,0.00006995618,0.00004409507,0.0003605505,0.0000361685,0.0009959363],"genre_scores_gemma":[0.9943878,0.0005490521,0.001628691,0.00008540464,0.00003724263,0.0001577873,0.0004203216,0.00001626704,0.00271743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002334347,"threshold_uncertainty_score":0.007809222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01316907939437225,"score_gpt":0.2417072567105182,"score_spread":0.2285381773161459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}