{"id":"W2937883307","doi":"10.1016/j.chom.2019.03.002","title":"An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity","year":2019,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":132,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; McGill University; Centre Hospitalier de l’Université de Montréal; Université de Montréal; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; University of Melbourne; Campbell Foundation","keywords":"Antibody-dependent cell-mediated cytotoxicity; Epitope; Gp41; Antibody; Biology; Glycoprotein; Human immunodeficiency virus (HIV); Cytotoxicity; Virology; Cell biology; Molecular biology; Immunology; Biochemistry; In vitro; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002314334,0.0002676974,0.0002488438,0.0001803361,0.0003317862,0.0007429743,0.0003119272,0.0004561974,0.002793787],"category_scores_gemma":[0.0003991965,0.0001411598,0.0003105702,0.0001033933,0.000347783,0.0005772661,0.0005485362,0.0008821688,0.0006444888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003786262,"about_ca_system_score_gemma":0.0001729658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001111505,"about_ca_topic_score_gemma":0.0000850678,"domain_scores_codex":[0.9997421,0.00003289814,0.00001135124,0.0000321909,0.000058335,0.0001231658],"domain_scores_gemma":[0.9997702,0.00006946165,0.00004532115,0.00004541366,0.00002212491,0.0000474052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002652718,0.00005205431,0.0002090174,0.00004117945,0.000005544623,0.0002681053,0.00003452998,0.0002474207,0.9907024,0.004405967,0.0001295423,0.003639043],"study_design_scores_gemma":[0.00004551846,0.000234651,0.002546278,0.000009399053,0.000008847582,0.0008117263,0.00007396609,0.003652981,0.9887758,0.001719428,0.002110558,0.0000108877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897618,0.0008459612,0.00360805,0.0001580193,0.00007596362,0.00002176786,0.00005689341,0.00004660772,0.005424921],"genre_scores_gemma":[0.9980353,0.0001832334,0.0004091557,0.00004575734,0.00001980418,0.000007051181,0.00004302553,0.00000817121,0.001248469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002793787,"threshold_uncertainty_score":0.009346128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008784045849218105,"score_gpt":0.2531666151722965,"score_spread":0.2443825693230784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}