{"id":"W2937883307","doi":"10.1016/j.chom.2019.03.002","title":"An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity","year":2019,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":132,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; McGill University; Centre Hospitalier de l’Université de Montréal; Université de Montréal; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; University of Melbourne; Campbell Foundation","keywords":"Antibody-dependent cell-mediated cytotoxicity; Epitope; Gp41; Antibody; Biology; Glycoprotein; Human immunodeficiency virus (HIV); Cytotoxicity; Virology; Cell biology; Molecular biology; Immunology; Biochemistry; In vitro; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003915054,0.000275746,0.0004792667,0.0003093237,0.000135237,0.00002942662,0.0005682718,0.0002632219,0.002678287],"category_scores_gemma":[0.00003091233,0.0002367816,0.0001314343,0.0003272614,0.0001609568,0.0001561374,0.0002271956,0.0003615124,0.01355514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007452711,"about_ca_system_score_gemma":0.0001451117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002421819,"about_ca_topic_score_gemma":0.00001164708,"domain_scores_codex":[0.9980761,0.0002625879,0.0003883636,0.0005230036,0.00008942461,0.0006604916],"domain_scores_gemma":[0.9988555,0.0001542542,0.0001702177,0.0006162124,0.0001147705,0.00008902496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001036912,0.000553534,0.06902207,0.00006326527,0.0001175446,0.00003112975,0.0003471354,0.000004268953,0.9284506,0.00002847518,0.0007536833,0.0005246093],"study_design_scores_gemma":[0.002247714,0.0005305919,0.01785516,0.00002992695,0.00003679513,0.00001742837,0.0002630679,0.000002518362,0.9713662,0.0000068137,0.007403712,0.0002400402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871189,0.005495416,0.0001886106,0.00004036292,0.000318106,0.0006075534,0.0003203929,0.00005115191,0.005859493],"genre_scores_gemma":[0.9916721,0.0003032632,0.0002852897,0.00004487734,0.00002376678,0.00001289914,0.001433913,0.00003450705,0.006189399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05116691,"threshold_uncertainty_score":0.9982334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008784045849218105,"score_gpt":0.2531666151722965,"score_spread":0.2443825693230784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}