{"id":"W2937919132","doi":"10.3389/fgene.2019.00304","title":"Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC","year":2019,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; University of Toronto; Krembil Foundation","funders":"National Center for Research Resources; National Research Foundation; National Institutes of Health; National Psoriasis Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Arthritis National Research Foundation","keywords":"Epigenomics; Genome-wide association study; Pharmacogenomics; Biology; Genetics; Computational biology; Psoriatic arthritis; Genetic association; Gene; Arthritis; Single-nucleotide polymorphism; Gene expression; Immunology; DNA methylation; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723189,0.0001815083,0.0003006567,0.00008084079,0.00009028446,0.00001866322,0.000176601,0.0001579119,0.00001574848],"category_scores_gemma":[0.00002696181,0.0001288689,0.00004987691,0.000140554,0.00007424563,0.00002131366,0.0000530519,0.0001124827,0.00005451334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004659492,"about_ca_system_score_gemma":0.00004141335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003117138,"about_ca_topic_score_gemma":0.0000422729,"domain_scores_codex":[0.9990568,0.0001027472,0.0002076143,0.0003149472,0.00002929862,0.0002885859],"domain_scores_gemma":[0.9995239,0.0000792685,0.00006220304,0.0002618911,0.00004721561,0.00002552133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00242105,0.0007414038,0.3519949,0.0001525618,0.0009966569,0.00000665611,0.01691058,0.0004274356,0.09985498,0.0005292424,0.2130254,0.3129391],"study_design_scores_gemma":[0.01456159,0.003018539,0.1298732,0.0001670632,0.0006128383,0.00006006075,0.0132914,0.000815829,0.6125519,0.004565932,0.2186637,0.001817902],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9654619,0.02437336,0.00430191,0.0001072787,0.002729651,0.001197991,0.0001517415,0.00001742795,0.001658752],"genre_scores_gemma":[0.9656196,0.002178126,0.02573884,0.0001492181,0.00008870262,0.00009727957,0.0001805541,0.0000257905,0.005921855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.512697,"threshold_uncertainty_score":0.525512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01027547317839405,"score_gpt":0.2105419830901878,"score_spread":0.2002665099117937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}