{"id":"W2937919132","doi":"10.3389/fgene.2019.00304","title":"Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC","year":2019,"lang":"en","type":"article","venue":"Frontiers in Genetics","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; University of Toronto; Krembil Foundation","funders":"National Center for Research Resources; National Research Foundation; National Institutes of Health; National Psoriasis Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Arthritis National Research Foundation","keywords":"Epigenomics; Genome-wide association study; Pharmacogenomics; Biology; Genetics; Computational biology; Psoriatic arthritis; Genetic association; Gene; Arthritis; Single-nucleotide polymorphism; Gene expression; Immunology; DNA methylation; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00110647,0.0004932203,0.0009811481,0.002600794,0.0003705847,0.0006748632,0.0005491184,0.0003673928,0.005628613],"category_scores_gemma":[0.0007503344,0.0003819843,0.001132527,0.001544198,0.0003751826,0.000236225,0.001181799,0.0009223911,0.0007363156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004074133,"about_ca_system_score_gemma":0.0005948883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001646949,"about_ca_topic_score_gemma":0.003691855,"domain_scores_codex":[0.9994054,0.0001279954,0.00003473261,0.0002219287,0.000137035,0.00007290165],"domain_scores_gemma":[0.9995566,0.0002014676,0.00007822246,0.00006477607,0.00003134823,0.00006761866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009959938,0.0002378102,0.01778932,0.0004253429,0.0005863374,0.00109686,0.0003484569,0.002628594,0.9000215,0.005024713,0.000707685,0.07013746],"study_design_scores_gemma":[0.001101977,0.002746324,0.5478532,0.0002642635,0.005110443,0.00537887,0.001075775,0.06674121,0.2479271,0.01902538,0.1025386,0.0002368246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6872885,0.004727381,0.2854358,0.0006848044,0.0001763535,0.0004861136,0.008268519,0.00137726,0.01155522],"genre_scores_gemma":[0.8151364,0.002591586,0.1683188,0.0006902278,0.0001028514,0.0004647282,0.007839276,0.0004109681,0.004445202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005628613,"threshold_uncertainty_score":0.01882958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01027547317839405,"score_gpt":0.2105419830901878,"score_spread":0.2002665099117937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}