{"id":"W2937929023","doi":"10.1002/cam4.1996","title":"Evaluation of vitamin D biosynthesis and pathway target genes reveals <i>UGT2A1/2</i> and <i>EGFR</i> polymorphisms associated with epithelial ovarian cancer in African American Women","year":2019,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre; Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; NIHR Cambridge Biomedical Research Centre; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; University of North Carolina at Chapel Hill; National Institutes of Health; Norges Forskningsråd; Helse Vest; Ministerio de Economía y Competitividad; Cancer Research UK; University College London; National Institute for Health and Care Research; U.S. Department of Defense; Lon V. Smith Foundation; American Association for Cancer Research; Radboud Universiteit; Canadian Institutes of Health Research; Cancer Institute NSW; Georgia Clinical and Translational Science Alliance; University of Cambridge; American Cancer Society; Moffitt Cancer Center; Minnesota Ovarian Cancer Alliance; Kreftforeningen; National Institute on Minority Health and Health Disparities; Mayo Foundation for Medical Education and Research; Princess Margaret Cancer Foundation; Oregon Health and Science University; Vanderbilt University; American Society of Preventive Oncology; Mayo Clinic; Ovarian Cancer Research Fund; North Carolina Central University; Oak Foundation","keywords":"Calcitriol receptor; CYP24A1; Single-nucleotide polymorphism; SNP; Biology; Vitamin D and neurology; Genotyping; Allele; Odds ratio; Oncology; Genetics; Genotype; Genome-wide association study; 1000 Genomes Project; Internal medicine; Gene; Medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00130261,0.0003011446,0.001028743,0.0002395153,0.00004028783,0.000008194773,0.00007127069,0.00008208508,0.0007268628],"category_scores_gemma":[0.0001456635,0.0002099945,0.0000322987,0.0006419969,0.0004098291,0.00007929363,0.00003120112,0.000139117,0.000001311154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009634236,"about_ca_system_score_gemma":0.0005317723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00578493,"about_ca_topic_score_gemma":0.001209334,"domain_scores_codex":[0.9975496,0.0002063234,0.0004446042,0.0005513713,0.0008339192,0.0004142019],"domain_scores_gemma":[0.9985082,0.0002154887,0.0003918296,0.0003171829,0.0003112953,0.0002560131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007211189,0.0002983708,0.7391384,0.0001537153,0.0007771801,0.0000273412,0.004439934,0.00004737888,0.04184528,0.00006506415,0.000198881,0.2122873],"study_design_scores_gemma":[0.01487833,0.002213846,0.9646666,0.002475354,0.001067644,0.00001243085,0.001747917,0.000414244,0.01090065,0.0001276356,0.001156091,0.0003392372],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821098,0.007933644,0.000004816374,0.007710718,0.0001796854,0.001096802,0.0002523398,0.00002267982,0.0006894997],"genre_scores_gemma":[0.9945889,0.003393325,0.0001203813,0.0008731787,0.0001980447,0.0006073285,0.00002409834,0.00004539218,0.0001493778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2255282,"threshold_uncertainty_score":0.8745123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645743529278758,"score_gpt":0.2703064647271695,"score_spread":0.2538490294343819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}