{"id":"W2937929023","doi":"10.1002/cam4.1996","title":"Evaluation of vitamin D biosynthesis and pathway target genes reveals <i>UGT2A1/2</i> and <i>EGFR</i> polymorphisms associated with epithelial ovarian cancer in African American Women","year":2019,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre; Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; NIHR Cambridge Biomedical Research Centre; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Medical Research Council; University of North Carolina at Chapel Hill; National Institutes of Health; Norges Forskningsråd; Helse Vest; Ministerio de Economía y Competitividad; Cancer Research UK; University College London; National Institute for Health and Care Research; U.S. Department of Defense; Lon V. Smith Foundation; American Association for Cancer Research; Radboud Universiteit; Canadian Institutes of Health Research; Cancer Institute NSW; Georgia Clinical and Translational Science Alliance; University of Cambridge; American Cancer Society; Moffitt Cancer Center; Minnesota Ovarian Cancer Alliance; Kreftforeningen; National Institute on Minority Health and Health Disparities; Mayo Foundation for Medical Education and Research; Princess Margaret Cancer Foundation; Oregon Health and Science University; Vanderbilt University; American Society of Preventive Oncology; Mayo Clinic; Ovarian Cancer Research Fund; North Carolina Central University; Oak Foundation","keywords":"Calcitriol receptor; CYP24A1; Single-nucleotide polymorphism; SNP; Biology; Vitamin D and neurology; Genotyping; Allele; Odds ratio; Oncology; Genetics; Genotype; Genome-wide association study; 1000 Genomes Project; Internal medicine; Gene; Medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004952449,0.0002673342,0.0002392715,0.0005948052,0.0003175893,0.0003414193,0.0002183792,0.0002802877,0.001811461],"category_scores_gemma":[0.001156095,0.0001370354,0.0004173981,0.0008594496,0.000208246,0.0001014916,0.0001738867,0.0002336241,0.0001263422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001623675,"about_ca_system_score_gemma":0.0001313152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004766863,"about_ca_topic_score_gemma":0.003313553,"domain_scores_codex":[0.9997337,0.0001030271,0.00001711741,0.00007128956,0.00004060833,0.00003409219],"domain_scores_gemma":[0.9996375,0.0001169135,0.0001471716,0.00002876984,0.00002962332,0.00003995014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001004252,0.00003226086,0.9809109,0.00003109084,0.0002204575,0.0002429672,0.0001217726,0.000163955,0.01242242,0.00009118502,0.0001637,0.004595095],"study_design_scores_gemma":[0.00003557988,0.0001816331,0.9944911,0.00001175136,0.000214824,0.0006796857,0.0001052883,0.000874767,0.002451577,0.00009945781,0.0008487301,0.000005671842],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988214,0.0003534711,0.0002788682,0.00004430907,0.000004519218,0.000007048469,0.0002789036,0.000006334545,0.0002052059],"genre_scores_gemma":[0.9992927,0.00006618609,0.000329387,0.00002128467,0.000004949628,0.000005917115,0.0001397995,0.000004111761,0.000135555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004766863,"threshold_uncertainty_score":0.009478211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645743529278758,"score_gpt":0.2703064647271695,"score_spread":0.2538490294343819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}