{"id":"W2937947516","doi":"10.1016/j.jtho.2019.04.008","title":"Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region","year":2019,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"National Institute of Environmental Health Sciences; Helmholtz Zentrum München; Health Technology Assessment Programme; National Institutes of Health; Instituto de Salud Carlos III; Xunta de Galicia; Bundesamt für Strahlenschutz; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Sheffield Hospitals Charity; Ministero della Salute; U.S. Department of Health and Human Services; Deutscher Akademischer Austauschdienst; National Institute for Health and Care Research; Society of Memorial Sloan Kettering; Janssen Pharmaceuticals; Memorial Sloan-Kettering Cancer Center; National Cancer Institute; Bayer; Cancer Prevention and Research Institute of Texas; AbbVie; Roy Castle Lung Cancer Foundation; World Health Organization; Canada Research Chairs; Medtronic; Takeda Pharmaceutical Company; Canadian Cancer Society Research Institute; Roche; Deutsche Forschungsgemeinschaft; Merck; Princess Margaret Hospital Foundation; Bristol-Myers Squibb; AstraZeneca; Philips","keywords":"Medicine; Variation (astronomy); Descent (aeronautics); Lung cancer; Lung; Oncology; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001899713,0.0001246842,0.0003635487,0.0001258811,0.00002889507,0.000006457584,0.0002719478,0.00020171,0.00001747218],"category_scores_gemma":[0.0002974124,0.00008660825,0.00009364183,0.0002092828,0.00004925954,0.000008437869,0.00004420574,0.000303357,0.000001611189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001862874,"about_ca_system_score_gemma":0.0002512072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819431,"about_ca_topic_score_gemma":0.0004178454,"domain_scores_codex":[0.997202,0.001589609,0.0006409483,0.0001842046,0.0001468021,0.0002364336],"domain_scores_gemma":[0.9982198,0.0001305487,0.001217492,0.0002099795,0.0001834554,0.00003875741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003977845,0.0002280617,0.977366,0.00001650725,0.0001618432,0.00003352186,0.001118104,0.004701514,0.007950219,0.000003422263,0.001378987,0.006643977],"study_design_scores_gemma":[0.0008788376,0.001007061,0.9942313,0.00007443901,0.0001093034,0.00005864284,0.0002648415,0.0006736826,0.0002622537,0.00005448331,0.002284334,0.0001007901],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963067,0.000674461,0.0006950347,0.001470107,0.0002124585,0.0002089998,0.000008660146,0.000001289727,0.0004223211],"genre_scores_gemma":[0.9972503,0.0009709771,0.0008287329,0.0007088525,0.0001147797,0.000005235189,0.000006596363,0.00001470715,0.00009986557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01686527,"threshold_uncertainty_score":0.3531782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370396878454702,"score_gpt":0.3335071091634444,"score_spread":0.3198031403788973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}