{"id":"W2938011530","doi":"10.1038/s41598-018-37647-8","title":"Bioinformatic discovery of a toxin family in Chryseobacterium piperi with sequence similarity to botulinum neurotoxins","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Wellcome Trust Centre for Mitochondrial Research; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Government of Canada; U.S. Department of Health and Human Services","keywords":"Biology; Toxin; Clostridium botulinum; Metalloproteinase; Botulism; Homology (biology); Genetics; Genome; Gene; Sequence homology; Protease; Computational biology; Peptide sequence; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001650966,0.0004048518,0.0003703677,0.0009395705,0.0004110123,0.0004312051,0.0001729597,0.0003648722,0.001395027],"category_scores_gemma":[0.0004783818,0.0001139749,0.0006157579,0.0009332196,0.0001753733,0.0002649263,0.0002926248,0.0003604701,0.0004962935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002204258,"about_ca_system_score_gemma":0.0002855781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006647799,"about_ca_topic_score_gemma":0.0009800382,"domain_scores_codex":[0.9998847,0.00001477996,0.00001132735,0.00003862759,0.00003239244,0.00001809425],"domain_scores_gemma":[0.9995881,0.0001107769,0.0001254015,0.00002652334,0.00005085476,0.00009842915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007779416,0.0001433704,0.02649701,0.0007058087,0.00007270119,0.002898384,0.0003181153,0.0007706538,0.9494449,0.0001908032,0.0006050563,0.01757532],"study_design_scores_gemma":[0.0001420749,0.001145466,0.750666,0.0002149805,0.0007477671,0.01944345,0.001302249,0.01790578,0.1816267,0.0008108552,0.02588626,0.0001084441],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877421,0.001397884,0.004976929,0.0003165857,0.00002765446,0.00009260244,0.003979106,0.00016397,0.001303252],"genre_scores_gemma":[0.9703316,0.001010397,0.01639559,0.0001955152,0.00003510194,0.00006464356,0.01085105,0.00005522705,0.001060806],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001395027,"threshold_uncertainty_score":0.004666805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01787027771828892,"score_gpt":0.2530565967219012,"score_spread":0.2351863190036123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}