{"id":"W2938132638","doi":"10.1097/mol.0000000000000484","title":"The ever-expanding saga of the proprotein convertases and their roles in body homeostasis: emphasis on novel proprotein convertase subtilisin kexin number 9 functions and regulation","year":2018,"lang":"en","type":"review","venue":"Current Opinion in Lipidology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"PCSK9; Proprotein convertase; Kexin; LDL receptor; Proprotein Convertases; Downregulation and upregulation; microRNA; Biology; Endocrinology; Lipoprotein; Cholesterol; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004267498,0.0006634526,0.00122761,0.001060584,0.0001798228,0.0009720594,0.0004714298,0.0008544461,0.002372546],"category_scores_gemma":[0.0006133178,0.0001535185,0.0005032977,0.001161423,0.0003523781,0.001417533,0.000560648,0.001691299,0.001074081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000398511,"about_ca_system_score_gemma":0.001062052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003993257,"about_ca_topic_score_gemma":0.0004076586,"domain_scores_codex":[0.9998119,0.00002338903,0.00003357879,0.00003749895,0.00007160455,0.00002200601],"domain_scores_gemma":[0.9994986,0.0001675993,0.00009380074,0.00001507415,0.0001590351,0.00006591919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003968368,0.00007540538,0.0009516535,0.02563214,0.000250311,0.001127962,0.0001504689,0.0004389686,0.01760696,0.00519306,0.09051267,0.8576636],"study_design_scores_gemma":[0.00002333903,0.0002410009,0.002819756,0.002483016,0.0001832694,0.004839717,0.000148156,0.0001558963,0.002802417,0.002594013,0.9836779,0.00003166295],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005640918,0.9957265,0.0003939552,0.001072675,0.00149528,0.00000467056,0.00003718912,0.0000189094,0.0006868923],"genre_scores_gemma":[0.002104951,0.9937535,0.0003576408,0.0006749668,0.002074578,0.000005475242,0.00008880159,0.00000556259,0.0009344649],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002372546,"threshold_uncertainty_score":0.007936895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08369572057341579,"score_gpt":0.3632198403536424,"score_spread":0.2795241197802266,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}