{"id":"W2938136921","doi":"10.1016/j.ejmech.2019.04.034","title":"Heterodimeric Rifampicin–Tobramycin conjugates break intrinsic resistance of Pseudomonas aeruginosa to doxycycline and chloramphenicol in vitro and in a Galleria mellonella in vivo model","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Pseudomonas aeruginosa; Efflux; Tobramycin; Chloramphenicol; Doxycycline; Microbiology; In vivo; Antibiotics; Chemistry; Rifampicin; Aminoglycoside; Antibacterial agent; Membrane permeability; Pyocyanin; Pharmacology; Bacteria; Biology; Biofilm; Gentamicin; Biochemistry; Quorum sensing; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009547625,0.000223481,0.0005249502,0.0001069822,0.00001131047,0.00001566254,0.0002541651,0.00008263476,0.00002156028],"category_scores_gemma":[0.000209242,0.0002060068,0.00004838467,0.0001669252,0.0001601237,0.00001286515,0.0001282202,0.0003017576,9.842366e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003584186,"about_ca_system_score_gemma":0.00008470866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009154104,"about_ca_topic_score_gemma":0.00002517993,"domain_scores_codex":[0.9981668,0.0001414271,0.0008682772,0.0003444675,0.0002160348,0.0002629666],"domain_scores_gemma":[0.9990825,0.00004540663,0.0003753639,0.0002624395,0.00007859079,0.0001556976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00307132,0.00007552079,0.02451567,0.0002163713,0.00001888546,0.000149258,0.0002122496,0.0001738416,0.9711666,0.000001089646,0.0001103544,0.0002888787],"study_design_scores_gemma":[0.004932964,0.0003095299,0.03593546,0.001182598,0.0000202735,0.0002087747,0.0005029951,0.0002126126,0.9557256,0.00003197554,0.0006172287,0.0003199816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970101,0.001439135,0.00008407123,0.0002147308,0.00005584141,0.0001595689,0.000009109317,0.000001980997,0.001025519],"genre_scores_gemma":[0.9972442,0.0006780456,0.001575386,0.0001349692,0.0001029093,7.864281e-7,0.000004750524,0.00002846873,0.0002304724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01544095,"threshold_uncertainty_score":0.8400714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006255366409287122,"score_gpt":0.2236963322603488,"score_spread":0.2174409658510617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}