{"id":"W2938136921","doi":"10.1016/j.ejmech.2019.04.034","title":"Heterodimeric Rifampicin–Tobramycin conjugates break intrinsic resistance of Pseudomonas aeruginosa to doxycycline and chloramphenicol in vitro and in a Galleria mellonella in vivo model","year":2019,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Pseudomonas aeruginosa; Efflux; Tobramycin; Chloramphenicol; Doxycycline; Microbiology; In vivo; Antibiotics; Chemistry; Rifampicin; Aminoglycoside; Antibacterial agent; Membrane permeability; Pyocyanin; Pharmacology; Bacteria; Biology; Biofilm; Gentamicin; Biochemistry; Quorum sensing; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941957,0.0004430191,0.0003470764,0.0001900732,0.0001483843,0.0003183168,0.0001902431,0.0004345133,0.0009090876],"category_scores_gemma":[0.00009310784,0.0002195061,0.0002103922,0.000161879,0.0002603226,0.0001953062,0.0001977889,0.0009558458,0.0003123471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003036469,"about_ca_system_score_gemma":0.0001666501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004934624,"about_ca_topic_score_gemma":0.0009647098,"domain_scores_codex":[0.9997295,0.00005743536,0.00002094424,0.00006655239,0.00006335266,0.00006219786],"domain_scores_gemma":[0.999838,0.00002183296,0.00005419015,0.00002938932,0.00001028429,0.00004630119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006395699,0.0000162932,0.00003587259,0.000009228907,0.000003836541,0.00001028301,0.000004429143,0.00002533854,0.9995847,0.00003853687,0.00001577586,0.0001916876],"study_design_scores_gemma":[0.00001946218,0.0002739609,0.001349801,0.000002563613,0.00001112409,0.00006935298,0.00001354475,0.0002502117,0.996973,0.00001074659,0.001023267,0.000002831109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956356,0.0008593914,0.002027041,0.0001384468,0.00004983048,0.00002721298,0.000185187,0.00007837432,0.0009988532],"genre_scores_gemma":[0.9962219,0.0002934661,0.001219111,0.00006490072,0.000008057265,0.00001612939,0.0002602779,0.00002405606,0.001892022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009090876,"threshold_uncertainty_score":0.003041208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006255366409287122,"score_gpt":0.2236963322603488,"score_spread":0.2174409658510617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}