{"id":"W2938159790","doi":"10.3389/fncel.2019.00121","title":"An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels","year":2019,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Ectodomain; Allosteric regulation; Inhibitory postsynaptic potential; Neuroscience; Biology; Receptor; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009588867,0.0003136631,0.0003276049,0.00008277564,0.0002154807,0.0002644274,0.0003447316,0.0003021965,0.00200724],"category_scores_gemma":[0.0001925931,0.0001377756,0.0002283142,0.00008921779,0.0003830871,0.0001939848,0.000269539,0.0003649309,0.0003050574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002936619,"about_ca_system_score_gemma":0.0003816734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001679192,"about_ca_topic_score_gemma":0.001550157,"domain_scores_codex":[0.9999294,0.00001224575,0.000004182399,0.00001713018,0.00002187633,0.00001509047],"domain_scores_gemma":[0.9999567,0.00001253982,0.0000108238,0.000004108545,0.00000517723,0.00001060381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008227897,0.0001583003,0.002723602,0.0002476206,0.00005876006,0.001729912,0.0001447515,0.02476015,0.954782,0.005899628,0.0005231795,0.008149297],"study_design_scores_gemma":[0.001052102,0.002485865,0.0280659,0.0001149334,0.0002946394,0.003410547,0.0004225079,0.3636483,0.5805954,0.004873432,0.01486583,0.0001705129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982905,0.0004653626,0.01266708,0.0001357194,0.00004172174,0.0000694986,0.0001951897,0.0001436049,0.00337674],"genre_scores_gemma":[0.9959732,0.0001546042,0.003125427,0.00004818503,0.000003883241,0.00002653848,0.00009198375,0.00001266107,0.0005635206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00200724,"threshold_uncertainty_score":0.00671488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008924751901002398,"score_gpt":0.2214359151682804,"score_spread":0.212511163267278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}