{"id":"W2938307111","doi":"10.1016/j.celrep.2019.03.047","title":"Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Calgary; University of Toronto","funders":"National Cancer Institute; Genome Canada; Canadian Institutes of Health Research; Cancer Prevention and Research Institute of Texas; University of Texas MD Anderson Cancer Center; Terry Fox Research Institute","keywords":"CRISPR; Biology; Temozolomide; Genome; Gene; Glioblastoma; Computational biology; Genetics; Cas9; Stem cell; Genome editing; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502169,0.0002606172,0.0002201122,0.0002945364,0.0001319468,0.0003899769,0.0001852828,0.0002339955,0.000977484],"category_scores_gemma":[0.0001695405,0.0001161968,0.0001673932,0.0001509394,0.0002505415,0.0001416092,0.0002861436,0.0003980977,0.0001637358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003140305,"about_ca_system_score_gemma":0.0002110224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199378,"about_ca_topic_score_gemma":0.003032414,"domain_scores_codex":[0.9998788,0.00001104718,0.00001211201,0.00003210038,0.00004573719,0.00002015703],"domain_scores_gemma":[0.9998976,0.00003007125,0.00003215678,0.00001450765,0.000009443515,0.00001624458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002986563,0.00001123945,0.0004874694,0.00002110456,0.000009203286,0.00006179303,0.00001679018,0.00034075,0.9965624,0.0003079201,0.00005610246,0.002095398],"study_design_scores_gemma":[0.000005066684,0.00007892455,0.005716433,0.000005157616,0.00001998607,0.0002511515,0.00003292438,0.003331267,0.9885245,0.0001914162,0.001837248,0.000005901805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831406,0.0004409461,0.01293175,0.0001174896,0.0000133862,0.00003760618,0.001087728,0.0004182611,0.001812265],"genre_scores_gemma":[0.9934632,0.0002838757,0.004431235,0.00006126703,0.000001763788,0.00002134722,0.0004318642,0.00003736466,0.001268167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199378,"threshold_uncertainty_score":0.00327003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004558563094037195,"score_gpt":0.219021731148994,"score_spread":0.2144631680549568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}