{"id":"W2938307111","doi":"10.1016/j.celrep.2019.03.047","title":"Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":247,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Calgary; University of Toronto","funders":"National Cancer Institute; Genome Canada; Canadian Institutes of Health Research; Cancer Prevention and Research Institute of Texas; University of Texas MD Anderson Cancer Center; Terry Fox Research Institute","keywords":"CRISPR; Biology; Temozolomide; Genome; Gene; Glioblastoma; Computational biology; Genetics; Cas9; Stem cell; Genome editing; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003450906,0.0002025888,0.0002856351,0.00007984906,0.0000238646,0.00001376101,0.00005549983,0.0001525979,0.0000179],"category_scores_gemma":[0.00002023842,0.0002123655,0.0000777129,0.00007434032,0.00005136756,0.000004124905,0.0001392308,0.00009766805,0.000003600934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001564962,"about_ca_system_score_gemma":0.00004735703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004517993,"about_ca_topic_score_gemma":0.00009117505,"domain_scores_codex":[0.998602,0.00005399182,0.0004333272,0.0004886028,0.0001400529,0.0002820491],"domain_scores_gemma":[0.9991292,0.00003563401,0.0001408885,0.0005400739,0.00006040019,0.00009376244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003201668,0.00003885258,0.01772748,0.0001360043,0.00001314758,0.0001516247,0.00009053256,0.003891644,0.9776314,0.000004268594,0.00002682707,0.0002561447],"study_design_scores_gemma":[0.0002532774,0.0002845377,0.01831626,0.00002037303,0.00001380408,0.0001569983,0.0003151774,0.0002025756,0.9796196,0.00009725843,0.0004908589,0.0002293403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863945,0.0008414183,0.01184184,0.000008923771,0.0001868872,0.0003391646,0.000006889815,0.00001237021,0.0003680535],"genre_scores_gemma":[0.9980302,0.00009436277,0.0009212485,0.00003400614,0.00003635474,0.000009506894,0.000005295074,0.00003261391,0.0008364076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01163575,"threshold_uncertainty_score":0.8660015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004558563094037195,"score_gpt":0.219021731148994,"score_spread":0.2144631680549568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}