{"id":"W2938542802","doi":"10.1016/j.euf.2019.04.004","title":"An Update on Predictive Biomarkers in Metastatic Renal Cell Carcinoma","year":2019,"lang":"en","type":"review","venue":"European Urology Focus","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Foothills Medical Centre; University of Calgary","funders":"","keywords":"Medicine; Sunitinib; Renal cell carcinoma; Nivolumab; Biomarker; Ipilimumab; Oncology; Internal medicine; Clinical trial; Targeted therapy; Intensive care medicine; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000798806,0.0009169843,0.002509037,0.0009506004,0.00004882721,0.0000237953,0.0004831744,0.0002280719,0.000194803],"category_scores_gemma":[0.00005542062,0.0006846553,0.0006370907,0.0004367341,0.000180303,0.00006555899,0.0001450164,0.00110622,0.004069033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000370542,"about_ca_system_score_gemma":0.0003915392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002941028,"about_ca_topic_score_gemma":0.000006214696,"domain_scores_codex":[0.9935049,0.003017884,0.001007315,0.001374834,0.0003653197,0.0007297202],"domain_scores_gemma":[0.9972329,0.0002832387,0.0005246554,0.001538752,0.00005655899,0.0003639072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001848081,0.001775945,0.0006085619,0.008630942,0.001942855,0.03719934,0.0002799903,0.00003135921,0.00003075571,0.00006970279,0.003498044,0.9440844],"study_design_scores_gemma":[0.004090569,0.01256775,0.003857845,0.001556221,0.00848416,0.001292006,0.00001886366,0.0000456522,0.00004719228,0.00001811612,0.9672151,0.0008065326],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003214853,0.9428201,0.0000193109,0.00007168875,0.0003452894,0.002214195,0.0001285285,0.00009187908,0.0510942],"genre_scores_gemma":[0.06765412,0.9292917,0.0002496442,0.0003624034,0.00029964,0.00009647531,0.0008892301,0.0003967621,0.0007600122],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.963717,"threshold_uncertainty_score":0.9995605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04694597014718582,"score_gpt":0.3023948541974595,"score_spread":0.2554488840502737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}