{"id":"W2938546950","doi":"10.1093/annonc/mdz094.003","title":"Effect of post-study immunotherapy (IO) on overall survival (OS) outcome in patients with metastatic (m) NSCLC treated with first-line durvalumab (D) vs chemotherapy (CT) in the phase III MYSTIC study","year":2019,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Phases of clinical research; Oncology; Pemetrexed; Chemotherapy; Nuclear medicine; Clinical trial; Surgery; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003971055,0.0005926088,0.001184816,0.0002635311,0.0001963093,0.0006714631,0.0005863587,0.0006709932,0.001607684],"category_scores_gemma":[0.0032196,0.0001745249,0.001539877,0.000226683,0.0005387078,0.0005705174,0.000519568,0.001667595,0.0001940629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005431069,"about_ca_system_score_gemma":0.0007149599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002358433,"about_ca_topic_score_gemma":0.000666676,"domain_scores_codex":[0.9988366,0.0006378488,0.00008989248,0.0001620533,0.0001023918,0.0001712647],"domain_scores_gemma":[0.9971784,0.00115914,0.0006001534,0.0003028107,0.00007949743,0.0006798502],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.833324,0.01065478,0.03670298,0.0004053037,0.001478098,0.00005365304,0.0001481705,0.00346586,0.008381674,0.0002478411,0.0006491928,0.1044885],"study_design_scores_gemma":[0.06952727,0.7208109,0.1917159,0.0000865761,0.001812724,0.0001421621,0.0001070144,0.005602943,0.007093491,0.0006833819,0.002365627,0.00005210306],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981381,0.0006116137,0.0002561655,0.00006608408,0.00003228979,0.0001776465,0.000170706,0.00001552292,0.000531905],"genre_scores_gemma":[0.9985653,0.0001670968,0.0002905908,0.00008133,0.00003675415,0.0002711628,0.0002748345,0.000006969827,0.0003060453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003971055,"threshold_uncertainty_score":0.02100122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03306078952820038,"score_gpt":0.3694570884408521,"score_spread":0.3363962989126517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}