{"id":"W2938767463","doi":"10.1039/c9fo00334g","title":"5-(3′,4′-Dihydroxyphenyl)-γ-valerolactone, a metabolite of procyanidins in cacao, suppresses MDI-induced adipogenesis by regulating cell cycle progression through direct inhibition of CDK2/cyclin O","year":2019,"lang":"en","type":"article","venue":"Food & Function","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"Ministry of Agriculture, Food and Rural Affairs; Ministry of Science, ICT and Future Planning","keywords":"Adipogenesis; Lipogenesis; Biochemistry; Adipocyte; Cell growth; Cyclin A; Biology; Chemistry; Lipid metabolism; Cyclin; Cell biology; Cell cycle; Cell; Adipose tissue","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006445247,0.0003452098,0.0001868818,0.0002370663,0.0001491088,0.0001527076,0.0001349322,0.0001630038,0.0005519171],"category_scores_gemma":[0.00005247813,0.0001229276,0.0001638131,0.0001492731,0.0001498667,0.0001330847,0.00009748004,0.0003553207,0.0001006454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001690249,"about_ca_system_score_gemma":0.000146145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006053359,"about_ca_topic_score_gemma":0.001191697,"domain_scores_codex":[0.9999597,0.000006000437,0.000003877996,0.00001108703,0.000009594225,0.000009778715],"domain_scores_gemma":[0.9999645,0.000004719253,0.00001306089,0.000003118801,0.000004231876,0.00001025019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000968592,0.00001455142,0.00009659932,0.00003687375,0.000002517118,0.00003181373,0.000006360562,0.00002097608,0.9986441,0.00001560842,0.000007864228,0.001025868],"study_design_scores_gemma":[0.00001613546,0.0004271126,0.004180352,0.000004123181,0.00001344471,0.0001461953,0.00001240474,0.000148999,0.9938452,0.00001614224,0.001186991,0.000002939598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926223,0.00434844,0.001432503,0.0000758928,0.000029712,0.00003051937,0.0001860638,0.00007960091,0.001195114],"genre_scores_gemma":[0.9943767,0.001783667,0.001718526,0.0000504501,0.00001418565,0.00002803767,0.0003160158,0.000009466203,0.001703033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006053359,"threshold_uncertainty_score":0.001846313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458830172757334,"score_gpt":0.2620971207429009,"score_spread":0.2475088190153275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}