{"id":"W2938767463","doi":"10.1039/c9fo00334g","title":"5-(3′,4′-Dihydroxyphenyl)-γ-valerolactone, a metabolite of procyanidins in cacao, suppresses MDI-induced adipogenesis by regulating cell cycle progression through direct inhibition of CDK2/cyclin O","year":2019,"lang":"en","type":"article","venue":"Food & Function","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"Ministry of Agriculture, Food and Rural Affairs; Ministry of Science, ICT and Future Planning","keywords":"Adipogenesis; Lipogenesis; Biochemistry; Adipocyte; Cell growth; Cyclin A; Biology; Chemistry; Lipid metabolism; Cyclin; Cell biology; Cell cycle; Cell; Adipose tissue","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003477518,0.0003032295,0.0008348597,0.0002244283,0.00005224113,0.00001020548,0.0000795485,0.0002727598,0.0001508733],"category_scores_gemma":[0.0001049004,0.0002699415,0.0001856667,0.0006414407,0.00004769439,0.0004565118,0.00005892431,0.0002361303,0.00002150163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005334252,"about_ca_system_score_gemma":0.0001078059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002651191,"about_ca_topic_score_gemma":0.00002971319,"domain_scores_codex":[0.9975705,0.0001546176,0.0008177162,0.0005196962,0.0005554809,0.0003820521],"domain_scores_gemma":[0.9985553,0.00008720982,0.0005705561,0.0004772315,0.000208823,0.0001008913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003172752,0.000696517,0.01679435,0.0007366443,0.0001172403,0.000001818509,0.0008521892,0.000034652,0.9725615,0.00007520167,0.00009568596,0.004861439],"study_design_scores_gemma":[0.003561576,0.004997041,0.02937757,0.0005807351,0.0004950039,0.000009277212,0.0002702125,0.0001647451,0.9577813,0.0001273783,0.002388928,0.0002462227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895626,0.005403825,0.00008588091,0.00006060207,0.0003852897,0.001359877,0.00005489629,0.00008333661,0.003003747],"genre_scores_gemma":[0.99832,0.000191564,0.0006333315,0.00005428524,0.0001683406,0.0000774397,0.0002249473,0.00006444468,0.0002656365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0147802,"threshold_uncertainty_score":0.9999753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458830172757334,"score_gpt":0.2620971207429009,"score_spread":0.2475088190153275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}