{"id":"W2938787379","doi":"10.1136/bmjopen-2018-028444","title":"Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol","year":2019,"lang":"en","type":"article","venue":"BMJ Open","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Centre Hospitalier de l’Université de Montréal; University of Toronto; St. Michael's Hospital; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Merck Canada; Gilead Sciences; Canadian HIV Trials Network, Canadian Institutes of Health Research; ViiV Healthcare; International AIDS Society; Yale University; Canadian Foundation for AIDS Research; Bristol-Myers Squibb","keywords":"Medicine; Metformin; Inflammation; Human immunodeficiency virus (HIV); Diabetes mellitus; Immune system; Antiretroviral therapy; Immunology; Viral load; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008780682,0.004764852,0.008071329,0.001294309,0.001512296,0.002253458,0.002852799,0.004462523,0.0384267],"category_scores_gemma":[0.006693644,0.001473688,0.004604232,0.001064014,0.002279232,0.001947962,0.001703578,0.003690995,0.006727567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001951272,"about_ca_system_score_gemma":0.006594746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001968442,"about_ca_topic_score_gemma":0.002961216,"domain_scores_codex":[0.996106,0.002026369,0.0003702235,0.0005100886,0.0003510588,0.0006363448],"domain_scores_gemma":[0.9952904,0.0008186686,0.001090973,0.0006068514,0.000922002,0.001271072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9721057,0.01375592,0.0003267219,0.002726267,0.000777641,0.00004825074,0.00005610539,0.00023919,0.001050271,0.0001883193,0.001518045,0.007207569],"study_design_scores_gemma":[0.8876998,0.1050179,0.001938128,0.0003910981,0.0006855289,0.00002261611,0.00004316436,0.0003941697,0.0003732523,0.0004242954,0.002969709,0.00004035316],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.09376677,0.002085316,0.003364377,0.0007931511,0.001219271,0.8887876,0.005559172,0.0002721698,0.004152043],"genre_scores_gemma":[0.09917514,0.001198534,0.005914364,0.001080276,0.0004623299,0.8856837,0.001320838,0.00003229286,0.005132471],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0384267,"threshold_uncertainty_score":0.1285501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06066558899950454,"score_gpt":0.4088454904106308,"score_spread":0.3481799014111263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}