{"id":"W2938872713","doi":"10.1111/trf.15300","title":"Platelet‐derived extracellular vesicles convey mitochondrial DAMPs in platelet concentrates and their levels are associated with adverse reactions","year":2019,"lang":"en","type":"article","venue":"Transfusion","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Natural Resources; Université Laval","funders":"Canadian Institutes of Health Research; Canadian Blood Services","keywords":"Platelet; Mitochondrial DNA; Mitochondrion; Extracellular; Immunology; Innate immune system; Extracellular vesicle; Biology; Extracellular vesicles; Neutrophil extracellular traps; Oxidative stress; Inner mitochondrial membrane; Damp; Mitochondrial ROS; Cell biology; Immune system; Inflammation; Microvesicles; Biochemistry; microRNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005927747,0.0002744241,0.000289127,0.0004830157,0.0001556089,0.0007985865,0.0001346517,0.0004143469,0.0008120993],"category_scores_gemma":[0.001684099,0.0001293562,0.0001959546,0.0003666296,0.0002164547,0.0002631937,0.0003094023,0.000481325,0.0001449174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001401174,"about_ca_system_score_gemma":0.00008482398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001534,"about_ca_topic_score_gemma":0.00008515586,"domain_scores_codex":[0.9992753,0.0001745571,0.000104155,0.00008279669,0.0002776002,0.0000857206],"domain_scores_gemma":[0.998574,0.0002961745,0.0008194785,0.00006354165,0.0001466651,0.0001001396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007879392,0.0003061558,0.3615636,0.0007560527,0.000709647,0.003036877,0.0006277124,0.0006321597,0.5883946,0.0004231317,0.0006132277,0.03505753],"study_design_scores_gemma":[0.00005725814,0.003157701,0.7769201,0.0001325174,0.0005612329,0.008412317,0.0005622844,0.002433063,0.203389,0.0003460977,0.003993201,0.00003513685],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923949,0.006221419,0.0007261654,0.00006126842,0.00002115646,0.00002127286,0.0001269577,0.00001580406,0.0004111201],"genre_scores_gemma":[0.9986215,0.0006850972,0.0003242966,0.00003735089,0.00002095001,0.00001421689,0.0001339429,0.000002623557,0.0001601203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008120993,"threshold_uncertainty_score":0.003134906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053680272031664,"score_gpt":0.2159556999493249,"score_spread":0.2054188972290083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}