{"id":"W2938872713","doi":"10.1111/trf.15300","title":"Platelet‐derived extracellular vesicles convey mitochondrial DAMPs in platelet concentrates and their levels are associated with adverse reactions","year":2019,"lang":"en","type":"article","venue":"Transfusion","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Natural Resources; Université Laval","funders":"Canadian Institutes of Health Research; Canadian Blood Services","keywords":"Platelet; Mitochondrial DNA; Mitochondrion; Extracellular; Immunology; Innate immune system; Extracellular vesicle; Biology; Extracellular vesicles; Neutrophil extracellular traps; Oxidative stress; Inner mitochondrial membrane; Damp; Mitochondrial ROS; Cell biology; Immune system; Inflammation; Microvesicles; Biochemistry; microRNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001531462,0.0002771546,0.0002708332,0.00005529251,0.0001084719,0.00003310206,0.0001487162,0.0002702079,0.0001064217],"category_scores_gemma":[0.00004974168,0.0002394953,0.00007483892,0.0001310373,0.0001805054,0.00002093133,0.00003349005,0.000215131,0.00001326768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003105952,"about_ca_system_score_gemma":0.00009198202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005174203,"about_ca_topic_score_gemma":0.0003819996,"domain_scores_codex":[0.9985138,0.0001482706,0.000301216,0.0005474337,0.0001442277,0.0003451011],"domain_scores_gemma":[0.9992759,0.00005992783,0.0001284182,0.0003353861,0.00006395427,0.0001364613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005786954,0.000170002,0.01293766,0.00003352862,0.00006652312,0.00004397292,0.0003524113,0.000201801,0.9849668,0.00002633058,0.00003323988,0.0005890397],"study_design_scores_gemma":[0.005149008,0.0002948629,0.03629683,0.0001874166,0.00002311638,0.00002453575,0.0008925552,0.0004111365,0.9539891,0.0000649947,0.0022481,0.0004183645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972096,0.001107131,0.00045676,0.00008776011,0.000159476,0.0006903454,0.0001161538,0.00003558082,0.000137174],"genre_scores_gemma":[0.9988043,0.0002950491,0.0001427215,0.00005806889,0.00006605345,0.00002218366,0.0002492175,0.00004511929,0.0003173212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03097771,"threshold_uncertainty_score":0.9766335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01053680272031664,"score_gpt":0.2159556999493249,"score_spread":0.2054188972290083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}