{"id":"W2938977814","doi":"10.1016/j.joca.2019.02.083","title":"Genome-wide analyses using UK biobank data povide new therapeutic targets for osteoarthritis","year":2019,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Genome-wide association study; Genetic association; Single-nucleotide polymorphism; Mendelian randomization; Linkage disequilibrium; Biobank; Expression quantitative trait loci; 1000 Genomes Project; Genetics; Biology; Disease; Genome; Bioinformatics; Heritability; Medicine; Computational biology; Gene; Genotype; Internal medicine; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002060991,0.000538734,0.001131829,0.00215473,0.0004415321,0.002036089,0.0003612954,0.0009612628,0.009344989],"category_scores_gemma":[0.007308882,0.0003018153,0.001286622,0.0061037,0.0004349615,0.0006477035,0.0009206101,0.0009182474,0.001487944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004922678,"about_ca_system_score_gemma":0.0008414672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008119293,"about_ca_topic_score_gemma":0.02194539,"domain_scores_codex":[0.998561,0.0004739817,0.0001846892,0.0003349712,0.0002962955,0.0001491212],"domain_scores_gemma":[0.994585,0.003083029,0.001268906,0.0004797635,0.0003663829,0.0002170712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007771884,0.0002531861,0.6747631,0.003518479,0.008991946,0.001324388,0.0008693218,0.00276771,0.02996353,0.004055257,0.06028167,0.2054395],"study_design_scores_gemma":[0.000276344,0.0002807325,0.9235858,0.0006802282,0.003306131,0.0007813125,0.0006236427,0.001219643,0.002814637,0.003331286,0.06302629,0.0000740231],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7031405,0.08939032,0.009631756,0.01665172,0.001088336,0.0001027161,0.1630921,0.000251098,0.01665141],"genre_scores_gemma":[0.924498,0.01700267,0.005900107,0.003295778,0.0003243028,0.00007165868,0.04617234,0.00008450997,0.002650603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009344989,"threshold_uncertainty_score":0.0312621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05831115648252572,"score_gpt":0.3155070198531715,"score_spread":0.2571958633706458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}