{"id":"W2939132899","doi":"10.1021/acscentsci.9b00284","title":"Design of Safe Nanotherapeutics for the Excretion of Excess Systemic Toxic Iron","year":2019,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; Canada Foundation for Innovation","keywords":"Excretion; Chemistry; Deferoxamine; Chelation; Pharmacology; Biodistribution; Conjugate; Thalassemia; Deferasirox; Spleen; Biochemistry; Medicine; Internal medicine; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004538101,0.00005917275,0.0001342701,0.00003521544,0.00006002455,0.000006216018,0.000188299,0.00005171782,0.00002248708],"category_scores_gemma":[0.00004591859,0.00003404161,0.00003725646,0.000304483,0.0002863955,0.00006510086,0.00001728423,0.00005299866,0.000003788626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004375132,"about_ca_system_score_gemma":0.0001852031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002019718,"about_ca_topic_score_gemma":4.137464e-7,"domain_scores_codex":[0.9991423,0.00001725828,0.0001850165,0.0001323532,0.0002783926,0.0002447055],"domain_scores_gemma":[0.9994559,0.0000972467,0.0001063606,0.0002020744,0.0000930858,0.00004527797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001386058,0.00005440712,0.004954279,0.0002406676,0.00001277035,3.062584e-7,0.000904348,0.00253119,0.9825671,0.0008801093,0.00003908138,0.00767715],"study_design_scores_gemma":[0.005405823,0.002402585,0.05363447,0.001573613,0.0003803163,0.00009734937,0.005529935,0.07773855,0.8505359,0.0004226451,0.001862818,0.0004159368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983369,0.001095882,0.01357212,0.0003956234,0.0003575354,0.0009549058,0.000002670135,0.000008611305,0.0002436432],"genre_scores_gemma":[0.9988473,0.0005020687,0.0003453184,0.00009985509,0.00001299366,0.000004338128,8.118908e-7,0.000004980149,0.0001823572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1320311,"threshold_uncertainty_score":0.1388177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01671590465658444,"score_gpt":0.2601483671771116,"score_spread":0.2434324625205271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}