{"id":"W2939216510","doi":"10.4155/bio-2018-0306","title":"Distribution of Heparan Sulfate and Dermatan Sulfate in Mucopolysaccharidosis Type Ii Mouse Tissues Pre- and Post-Enzyme-Replacement Therapy Determined By Uplc–Ms/Ms","year":2019,"lang":"en","type":"article","venue":"Bioanalysis","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Általános Orvostudományi Kar, Pécsi Tudományegyetem","keywords":"Mucopolysaccharidosis type II; Dermatan sulfate; Enzyme replacement therapy; Heparan sulfate; Hunter syndrome; Chemistry; Enzyme; Mucopolysaccharidosis; Glycosaminoglycan; Chromatography; Enzyme assay; Biochemistry; Molecular biology; Internal medicine; Medicine; Biology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003678007,0.0005612115,0.0002134908,0.0008076244,0.0001815185,0.0003016139,0.0001441754,0.000403541,0.0006431104],"category_scores_gemma":[0.0001810744,0.0001607805,0.0002085995,0.0002580431,0.0002838049,0.0002363261,0.0001513593,0.000440979,0.0002406511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002251936,"about_ca_system_score_gemma":0.0002308254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005467031,"about_ca_topic_score_gemma":0.001017163,"domain_scores_codex":[0.9997928,0.00002291338,0.00001606062,0.00007436037,0.00006657793,0.00002726522],"domain_scores_gemma":[0.9997929,0.00002315219,0.00008423508,0.00001242132,0.0000486096,0.00003862323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009627471,0.000009125079,0.0004118502,0.00003058844,0.000007513297,0.00002539467,0.00001359213,0.00001708234,0.9982445,0.00002155863,0.00002621141,0.001096416],"study_design_scores_gemma":[0.00000657379,0.0002554095,0.0115155,0.00001373316,0.00004263386,0.0002894809,0.00003253032,0.0004532855,0.9860701,0.00004522908,0.001263032,0.00001242644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655991,0.006363352,0.02246058,0.0001637225,0.00007392709,0.00009330299,0.002805335,0.0006027033,0.001838084],"genre_scores_gemma":[0.9452946,0.004995991,0.03938737,0.0003501379,0.00003854705,0.0003439782,0.002124407,0.0001447678,0.007320235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008076244,"threshold_uncertainty_score":0.00215137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218244786373586,"score_gpt":0.2851833936400487,"score_spread":0.2730009457763129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}