{"id":"W2939216510","doi":"10.4155/bio-2018-0306","title":"Distribution of Heparan Sulfate and Dermatan Sulfate in Mucopolysaccharidosis Type Ii Mouse Tissues Pre- and Post-Enzyme-Replacement Therapy Determined By Uplc–Ms/Ms","year":2019,"lang":"en","type":"article","venue":"Bioanalysis","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Általános Orvostudományi Kar, Pécsi Tudományegyetem","keywords":"Mucopolysaccharidosis type II; Dermatan sulfate; Enzyme replacement therapy; Heparan sulfate; Hunter syndrome; Chemistry; Enzyme; Mucopolysaccharidosis; Glycosaminoglycan; Chromatography; Enzyme assay; Biochemistry; Molecular biology; Internal medicine; Medicine; Biology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003104319,0.0002273928,0.0005829243,0.0002535958,0.00007820879,0.00003651813,0.0001252069,0.0001570637,0.0003294226],"category_scores_gemma":[0.00009231121,0.0001887705,0.00008861296,0.0006507408,0.0001316598,0.0001493272,0.0001218719,0.0001702178,0.00001050088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001084311,"about_ca_system_score_gemma":0.00004976345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004413743,"about_ca_topic_score_gemma":0.0002834038,"domain_scores_codex":[0.9982294,0.0001051189,0.0004331293,0.0004532201,0.0004349329,0.0003441251],"domain_scores_gemma":[0.9990005,0.00005621764,0.000139583,0.0004328023,0.0002061309,0.0001647134],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002496165,0.000512691,0.6449651,0.0001919438,0.000689043,0.00001471206,0.0008497996,0.000005454373,0.339483,0.00001573962,0.0003533022,0.01042306],"study_design_scores_gemma":[0.01432498,0.003777922,0.5382578,0.0001928661,0.0007674507,0.00003342178,0.000846101,0.009431547,0.4246953,0.00002964752,0.006772948,0.0008699779],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888087,0.009502915,0.000024429,0.0007596359,0.00002368963,0.0006520384,0.0001425878,0.0000281464,0.00005786581],"genre_scores_gemma":[0.9935416,0.00418828,0.00004227498,0.00007205904,0.00001268441,0.00002371439,0.000434739,0.00002388907,0.001660743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1067072,"threshold_uncertainty_score":0.7697837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218244786373586,"score_gpt":0.2851833936400487,"score_spread":0.2730009457763129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}