{"id":"W2939235761","doi":"10.1080/2162402x.2019.1599636","title":"Daratumumab in combination with urelumab to potentiate anti-myeloma activity in lymphocyte-deficient mice reconstituted with human NK cells","year":2019,"lang":"en","type":"article","venue":"OncoImmunology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"H2020 European Institute of Innovation and Technology; Instituto de Salud Carlos III; Worldwide Cancer Research","keywords":"Daratumumab; Antibody-dependent cell-mediated cytotoxicity; CD137; Cancer research; CD38; Medicine; Monoclonal antibody; Immunology; CD8; Multiple myeloma; Immunotherapy; Antibody; Immune system; Biology; Cell biology; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002039948,0.0002466265,0.0005625906,0.0006193258,0.00008043395,0.00002339439,0.0001526562,0.0001612916,0.0001044286],"category_scores_gemma":[0.00002267667,0.0001922716,0.00003816398,0.0006636471,0.0001400916,0.0001464411,0.0000804584,0.0003561121,0.0003121017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000884332,"about_ca_system_score_gemma":0.0003816386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002207632,"about_ca_topic_score_gemma":0.002283271,"domain_scores_codex":[0.9981652,0.0001562036,0.000258252,0.000539897,0.0002892918,0.000591154],"domain_scores_gemma":[0.9991332,0.00006016935,0.0001066311,0.0004802031,0.0001132494,0.0001065248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.009195141,0.003710001,0.332408,0.0001545272,0.0002916448,0.001732069,0.0006505332,0.0003094301,0.6315078,0.000397277,0.0000363411,0.0196072],"study_design_scores_gemma":[0.02824193,0.004205762,0.9206378,0.000430061,0.00003234902,0.0002192537,0.0002214455,0.0002784736,0.04486164,0.00001136562,0.0006018059,0.0002580881],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933282,0.0001433228,0.00005193185,0.0003318881,0.0001451822,0.001453263,0.00001545648,0.00004792395,0.004482829],"genre_scores_gemma":[0.9984959,0.00004105929,0.0003839482,0.00007551644,0.000009802859,0.00008571269,0.00008364826,0.00003014851,0.0007942357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5882298,"threshold_uncertainty_score":0.7840608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318875039606855,"score_gpt":0.2748000952713961,"score_spread":0.2616113448753276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}