{"id":"W2939282535","doi":"10.1016/j.molmet.2019.04.003","title":"An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer","year":2019,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University of British Columbia; University Health Network","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Princess Margaret Cancer Foundation; University of Pennsylvania","keywords":"Statin; Fluvastatin; Cancer research; Prostate cancer; Apoptosis; Downregulation and upregulation; Programmed cell death; HMG-CoA reductase; Mevalonate pathway; Pharmacology; Biology; Chemistry; Medicine; Internal medicine; Cancer; Reductase; Biochemistry; Simvastatin; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004096253,0.0003814323,0.0004854845,0.0001531955,0.00006378881,0.00007638436,0.0001996135,0.0001800268,0.0001205966],"category_scores_gemma":[0.00002796713,0.0003897081,0.0001523058,0.0003096284,0.00007800965,0.00003668373,0.0001065216,0.0002260302,0.00004499744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003693278,"about_ca_system_score_gemma":0.000199558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001296992,"about_ca_topic_score_gemma":0.0006506758,"domain_scores_codex":[0.9975582,0.0002637804,0.000376876,0.0008511035,0.0003169176,0.0006331467],"domain_scores_gemma":[0.9986758,0.000008469316,0.0001524737,0.000782069,0.000191318,0.0001898442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002525369,0.000135895,0.004679058,0.00003361826,0.00008990085,0.000002513911,0.0001458273,0.01070711,0.9776902,0.000140541,0.0008481328,0.00527469],"study_design_scores_gemma":[0.003505769,0.0001063209,0.1216169,0.00004051872,0.00008820329,0.0000242104,0.0001699529,0.002298842,0.6335071,0.0001991627,0.2375971,0.0008458606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894238,0.004927641,0.0003534734,0.0001626878,0.004032139,0.0006772331,0.0001083384,0.00004127538,0.0002734635],"genre_scores_gemma":[0.9935242,0.0007215559,0.0005616095,0.0007677611,0.001606103,0.00009466083,0.0003017737,0.00009170103,0.002330664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.344183,"threshold_uncertainty_score":0.9998555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004811803904226202,"score_gpt":0.2407800304839757,"score_spread":0.2359682265797495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}