{"id":"W2939282535","doi":"10.1016/j.molmet.2019.04.003","title":"An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer","year":2019,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University of British Columbia; University Health Network","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Princess Margaret Cancer Foundation; University of Pennsylvania","keywords":"Statin; Fluvastatin; Cancer research; Prostate cancer; Apoptosis; Downregulation and upregulation; Programmed cell death; HMG-CoA reductase; Mevalonate pathway; Pharmacology; Biology; Chemistry; Medicine; Internal medicine; Cancer; Reductase; Biochemistry; Simvastatin; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893993,0.0002604855,0.0003686065,0.0003075999,0.0002020508,0.0003991737,0.0002072235,0.000206727,0.001115227],"category_scores_gemma":[0.0002013686,0.0001462624,0.0002797887,0.000262508,0.0002208646,0.0001434413,0.0002107988,0.0004396531,0.0002515712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003532178,"about_ca_system_score_gemma":0.0003291621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008075475,"about_ca_topic_score_gemma":0.001141109,"domain_scores_codex":[0.9998066,0.00003898078,0.00001403904,0.00003246992,0.00006192194,0.00004596161],"domain_scores_gemma":[0.9998734,0.0000191492,0.00004011087,0.00001210844,0.00002677917,0.00002835788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002914295,0.00004166979,0.001726612,0.00006396419,0.00001557275,0.00004143117,0.00001874615,0.00008191677,0.9957665,0.00004573154,0.00003736265,0.001869042],"study_design_scores_gemma":[0.00004534678,0.0009481491,0.08051027,0.00001380105,0.0001148293,0.0004929518,0.00008299179,0.003142554,0.9125496,0.00008715757,0.001993568,0.00001871054],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932006,0.003684317,0.001931583,0.0001033138,0.00002229629,0.00003615603,0.0002691223,0.000118649,0.0006340587],"genre_scores_gemma":[0.997919,0.0008064602,0.0005062271,0.00002898592,0.000005798168,0.00001732454,0.000159347,0.000005696606,0.0005511533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001115227,"threshold_uncertainty_score":0.003730834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004811803904226202,"score_gpt":0.2407800304839757,"score_spread":0.2359682265797495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}