{"id":"W2939348335","doi":"10.1093/hmg/ddz080","title":"The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson’s disease","year":2019,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Parkinson Society Canada","keywords":"Parkin; Mitophagy; Biology; Genetics; Parkinson's disease; Ubiquitin ligase; Mutation; Ubiquitin; Pathogenesis; Disease; Immunology; Gene; Medicine; Internal medicine; Autophagy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242794,0.0002148897,0.0003054895,0.00009127536,0.00007862588,0.00002452496,0.0001303195,0.00007655057,0.00008446783],"category_scores_gemma":[0.00001678874,0.0001612317,0.0001094638,0.0001235025,0.00004504761,0.00001390751,0.00007568864,0.0001035605,0.00001851592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002749645,"about_ca_system_score_gemma":0.00007336814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005285667,"about_ca_topic_score_gemma":0.000008098871,"domain_scores_codex":[0.9985449,0.0001232757,0.0003034756,0.0003778368,0.0003255871,0.0003249199],"domain_scores_gemma":[0.9990082,0.000032164,0.0001178358,0.0005718182,0.00005158746,0.0002183558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006534781,0.0009327651,0.2396019,0.000294956,0.000650013,0.001027286,0.0003806429,0.00008927408,0.7270837,0.01789049,0.00006028599,0.0113352],"study_design_scores_gemma":[0.002748773,0.0004541541,0.9650522,0.000100924,0.0003329059,0.00001431498,0.0000632478,0.0008255286,0.003535652,0.02485064,0.001812858,0.0002087599],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807491,0.01760224,0.0003742597,0.00007752241,0.00007839576,0.0007628576,0.00002853255,0.00001654859,0.0003105529],"genre_scores_gemma":[0.9980772,0.0006877354,0.0006659383,0.0002699157,0.00001557032,0.00004815272,0.00003164146,0.00004213196,0.0001617388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7254503,"threshold_uncertainty_score":0.6574838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182412775364931,"score_gpt":0.2508079815031562,"score_spread":0.2389838537495069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}