{"id":"W2939348335","doi":"10.1093/hmg/ddz080","title":"The landscape of Parkin variants reveals pathogenic mechanisms and therapeutic targets in Parkinson’s disease","year":2019,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Parkinson Society Canada","keywords":"Parkin; Mitophagy; Biology; Genetics; Parkinson's disease; Ubiquitin ligase; Mutation; Ubiquitin; Pathogenesis; Disease; Immunology; Gene; Medicine; Internal medicine; Autophagy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000427651,0.0002361009,0.0003716612,0.0003114521,0.0001927971,0.0005828014,0.0001498134,0.0002397013,0.0004795982],"category_scores_gemma":[0.0004143453,0.0001137105,0.0001817391,0.0001993701,0.0003135112,0.0003441418,0.0002550558,0.0002941859,0.00009058118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002857039,"about_ca_system_score_gemma":0.0001854654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002660387,"about_ca_topic_score_gemma":0.0006219207,"domain_scores_codex":[0.9998735,0.00003940186,0.00001207138,0.00003195446,0.00002909495,0.00001395373],"domain_scores_gemma":[0.9998921,0.00002984137,0.00004174001,0.000007972802,0.00001311216,0.00001519653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001982983,0.0003636191,0.1056342,0.0004379996,0.0003819056,0.002534089,0.000377911,0.02877554,0.5505098,0.006879278,0.001123516,0.3009992],"study_design_scores_gemma":[0.0007252985,0.01085026,0.4440995,0.0005086675,0.001399289,0.01962618,0.001306837,0.1318267,0.2965269,0.05331039,0.03964458,0.0001753862],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783531,0.01510727,0.003959793,0.0006796306,0.00001080865,0.00002021076,0.00008319248,0.00007265199,0.001713346],"genre_scores_gemma":[0.9954861,0.002898157,0.001307884,0.00009772961,0.00001166669,0.00000475057,0.00006897687,0.000007031045,0.0001177577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005828014,"threshold_uncertainty_score":0.002261639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182412775364931,"score_gpt":0.2508079815031562,"score_spread":0.2389838537495069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}