{"id":"W2939378295","doi":"10.1126/sciimmunol.aav6778","title":"AIRE expression controls the peripheral selection of autoreactive B cells","year":2019,"lang":"en","type":"article","venue":"Science Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Jeffrey Modell Foundation; Agency for Science, Technology and Research; Donald E. and Delia B. Baxter Foundation","keywords":"Selection (genetic algorithm); Immunology; Biology; Negative selection; Peripheral; Peripheral tolerance; Expression (computer science); Cell biology; T cell; Immune system; Medicine; Gene; Genetics; Computer science; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006257622,0.0002295182,0.0004168095,0.0002075026,0.0005176471,0.00002162423,0.001003868,0.0003388402,0.001769847],"category_scores_gemma":[0.00008072646,0.0001499643,0.0001252776,0.0005524583,0.00306771,0.0003073613,0.0002804019,0.000593991,0.0009808034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001177764,"about_ca_system_score_gemma":0.0003333938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002396967,"about_ca_topic_score_gemma":0.00001186813,"domain_scores_codex":[0.9979395,0.0003269686,0.0003925845,0.0005356099,0.00008799749,0.0007173509],"domain_scores_gemma":[0.9985917,0.0002383046,0.0003240489,0.0005849437,0.0002438263,0.00001721801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002543597,0.0001226082,0.001809112,0.000004562996,0.00006780333,6.882741e-7,0.0007010411,0.00001925815,0.9928541,0.001726381,0.0002643673,0.002175751],"study_design_scores_gemma":[0.001306044,0.0006320107,0.007295068,0.00001989534,0.00001875123,0.00009021364,0.001076119,0.00003021779,0.9742746,0.0002185839,0.01486552,0.0001730094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905718,0.001392116,0.00007684117,0.0003278301,0.003351205,0.00046452,0.000006735987,0.00008072788,0.003728223],"genre_scores_gemma":[0.9945341,0.00005801684,0.00006055242,0.0001317839,0.00002278718,0.00003023114,0.000008066374,0.00001359472,0.005140829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0185795,"threshold_uncertainty_score":0.999797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005753811843489468,"score_gpt":0.221177605022414,"score_spread":0.2154237931789246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}