{"id":"W2939378295","doi":"10.1126/sciimmunol.aav6778","title":"AIRE expression controls the peripheral selection of autoreactive B cells","year":2019,"lang":"en","type":"article","venue":"Science Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Jeffrey Modell Foundation; Agency for Science, Technology and Research; Donald E. and Delia B. Baxter Foundation","keywords":"Selection (genetic algorithm); Immunology; Biology; Negative selection; Peripheral; Peripheral tolerance; Expression (computer science); Cell biology; T cell; Immune system; Medicine; Gene; Genetics; Computer science; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002438777,0.0002262503,0.0002920743,0.0003038453,0.0002866665,0.0007888445,0.0002710264,0.0002901965,0.002573445],"category_scores_gemma":[0.0002731979,0.0002114934,0.0001643167,0.0001194595,0.0005058075,0.0002944491,0.0004329331,0.0009597926,0.001078159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000268854,"about_ca_system_score_gemma":0.0001902168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002964713,"about_ca_topic_score_gemma":0.0007687338,"domain_scores_codex":[0.9995891,0.00006099163,0.0000256666,0.00009277551,0.00008797381,0.0001435361],"domain_scores_gemma":[0.9995478,0.000101986,0.00009408247,0.00006393456,0.0000466121,0.0001455307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001259891,0.00002430349,0.0003345816,0.00001078995,0.000001620919,0.00003355401,0.000009923257,0.00003129045,0.9981008,0.0002217128,0.00004327585,0.001062097],"study_design_scores_gemma":[0.00003318107,0.0001118372,0.008365526,0.000008641646,0.000009227021,0.0003079306,0.0000478663,0.001528374,0.9857525,0.0001514665,0.003676761,0.000006755869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932221,0.001173638,0.002396683,0.0001120377,0.0000522649,0.00001032345,0.0001697708,0.0001330559,0.002730151],"genre_scores_gemma":[0.9948479,0.000255985,0.000946497,0.0000459186,0.00001576003,0.00001079147,0.000176134,0.00005106134,0.003650049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002573445,"threshold_uncertainty_score":0.008608997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005753811843489468,"score_gpt":0.221177605022414,"score_spread":0.2154237931789246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}