{"id":"W2939381881","doi":"10.1084/jem.20190185","title":"Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy","year":2019,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Morris and Alma Schapiro Fund","keywords":"Systemic lupus erythematosus; Pregnancy; Preeclampsia; Immunology; Transcriptome; Medicine; Fetus; Immune system; Andrology; Biology; Internal medicine; Gene expression; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00111747,0.0001443766,0.0006980915,0.0002902788,0.00003500679,0.000002869194,0.0001740577,0.00005651845,0.0001698557],"category_scores_gemma":[0.00005132253,0.00007960996,0.0000599032,0.0002227683,0.0002446605,0.00008864446,0.00003627016,0.0003761369,0.00000233527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008759719,"about_ca_system_score_gemma":0.00008736109,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006315805,"about_ca_topic_score_gemma":0.000003292889,"domain_scores_codex":[0.9979044,0.0001491989,0.0008554173,0.0001251196,0.0007180027,0.0002478628],"domain_scores_gemma":[0.9989981,0.0001477021,0.0003329141,0.0002448401,0.000117521,0.0001588941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001104121,0.0002474721,0.3393115,0.0005098523,0.00007237458,0.00006761406,0.006907341,3.78711e-7,0.651588,0.0001110999,0.00003241476,0.00004790552],"study_design_scores_gemma":[0.05510005,0.04055463,0.03171846,0.03131122,0.0004179534,0.09271066,0.0603864,0.00007200738,0.6872496,0.0001668917,0.00003155341,0.000280576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9509582,0.0463433,0.000005358779,0.000752955,0.0003247451,0.0006686862,6.616746e-7,0.000004643531,0.0009414647],"genre_scores_gemma":[0.9989092,0.0005271644,0.0001000704,0.00005789437,0.0001586721,0.000004745807,9.773173e-7,0.00002053024,0.0002207438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.307593,"threshold_uncertainty_score":0.32464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04453396006892991,"score_gpt":0.3640844292273341,"score_spread":0.3195504691584042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}