{"id":"W2939524357","doi":"10.1016/j.psyneuen.2019.04.011","title":"Polygenic risk for circulating reproductive hormone levels and their influence on hippocampal volume and depression susceptibility","year":2019,"lang":"en","type":"article","venue":"Psychoneuroendocrinology","topic":"Birth, Development, and Health","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Medical Research Council; National Institute for Health and Care Research","keywords":"Polygenic risk score; Depression (economics); Hippocampal formation; Hormone; Brain size; Internal medicine; Psychology; Medicine; Endocrinology; Physiology; Biology; Genetics; Single-nucleotide polymorphism; Gene; Genotype; Economics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001067302,0.0003130125,0.0003230947,0.0007191504,0.0002537852,0.0005030053,0.0002678074,0.0003430808,0.001684175],"category_scores_gemma":[0.002848471,0.0001974622,0.0008403367,0.0009140683,0.0002687051,0.0001725229,0.0004206927,0.0003391386,0.0001223138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001312032,"about_ca_system_score_gemma":0.0001908368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007591871,"about_ca_topic_score_gemma":0.0071115,"domain_scores_codex":[0.9991568,0.0003213926,0.00007600342,0.0002952759,0.00007459027,0.0000758897],"domain_scores_gemma":[0.998535,0.0005826416,0.0003833394,0.0003056131,0.00007608168,0.0001173661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002534621,0.00001852386,0.9918682,0.00001093491,0.0007900422,0.0002471537,0.00008655534,0.0005125851,0.003077881,0.0001713637,0.0001172569,0.00284607],"study_design_scores_gemma":[0.000007659448,0.00004594341,0.9979336,0.000002479649,0.0001469473,0.0002379188,0.00002522281,0.001232613,0.0001324384,0.0001427367,0.00008807454,0.000004363976],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997809,0.0001485321,0.001229103,0.00003276958,0.000004127925,0.00000672107,0.0005595746,0.00001827757,0.0001920163],"genre_scores_gemma":[0.9990007,0.00004161754,0.0004270831,0.000008913331,0.000003835086,0.000005897952,0.0004377846,0.000004139372,0.0000699862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007591871,"threshold_uncertainty_score":0.01509535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02711263412738463,"score_gpt":0.3032757210741678,"score_spread":0.2761630869467832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}