{"id":"W2939562813","doi":"10.1124/jpet.118.255679","title":"Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation","year":2019,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of British Columbia","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Canadian Association of Gastroenterology; University of Calgary; Cumming School of Medicine, University of Calgary; U.S. Department of Defense; Alberta Innovates; National Institute of Environmental Health Sciences; Crohn's and Colitis Canada","keywords":"Pregnane X receptor; Inflammasome; Cell biology; Innate immune system; Receptor; Nuclear receptor; Signal transduction; Biology; Chemistry; Pharmacology; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002457846,0.0002587894,0.0002995738,0.0001646467,0.000158704,0.00028175,0.0001355473,0.0003499033,0.002083506],"category_scores_gemma":[0.0001766257,0.0001163804,0.0003083701,0.0001184012,0.0002264108,0.0003108564,0.0003357974,0.0005285214,0.0004883505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002072619,"about_ca_system_score_gemma":0.0002371466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001171105,"about_ca_topic_score_gemma":0.0001783364,"domain_scores_codex":[0.9997336,0.00005904888,0.00002637165,0.00004546508,0.00005456152,0.00008089975],"domain_scores_gemma":[0.9999152,0.00001142049,0.00002823194,0.00001275434,0.000009213893,0.00002318651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003662373,0.0000339744,0.0002661515,0.00006511222,0.000005988528,0.0003729435,0.00003465783,0.00003009647,0.9973642,0.0001885573,0.00006357662,0.001208495],"study_design_scores_gemma":[0.00008472461,0.0006305892,0.009711137,0.00002090953,0.00001659884,0.001189323,0.0001357464,0.0008229435,0.9840009,0.0005238101,0.002854097,0.000009119472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877909,0.003705654,0.005162014,0.0004431776,0.0001427752,0.00007843477,0.0003003562,0.000100057,0.002276674],"genre_scores_gemma":[0.995169,0.0009299896,0.001620737,0.0001536333,0.00004055629,0.00007520407,0.0001703856,0.000007646559,0.001832803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002083506,"threshold_uncertainty_score":0.006970048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01380040356769194,"score_gpt":0.2880642619253291,"score_spread":0.2742638583576372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}