{"id":"W2939564206","doi":"10.1002/pros.23808","title":"PTEN‐deficient prostate cancer is associated with an immunosuppressive tumor microenvironment mediated by increased expression of IDO1 and infiltrating FoxP3+ T regulatory cells","year":2019,"lang":"en","type":"article","venue":"The Prostate","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Prostate Cancer Canada","keywords":"PTEN; FOXP3; Cancer research; Prostate; Tumor microenvironment; Prostate cancer; Cancer; Medicine; Internal medicine; Biology; Pathology; Immunology; Immune system; Signal transduction; PI3K/AKT/mTOR pathway; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001389882,0.0002681263,0.0002860536,0.0008147691,0.0001650527,0.0003485843,0.0001628104,0.0001303784,0.001633494],"category_scores_gemma":[0.0001844097,0.0001502758,0.0002216335,0.0004758498,0.0002418318,0.000127019,0.000258934,0.0002379087,0.0002251071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002033256,"about_ca_system_score_gemma":0.0002306169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005905053,"about_ca_topic_score_gemma":0.0007525169,"domain_scores_codex":[0.9998373,0.00001272521,0.000007886266,0.00004598871,0.00006334692,0.00003285232],"domain_scores_gemma":[0.9997826,0.00002002,0.0001052117,0.0000145719,0.00001508821,0.0000623723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006829059,0.00004941282,0.07022271,0.000118019,0.00007327639,0.0003952773,0.00005526652,0.0002881022,0.9214749,0.0000991178,0.0002034345,0.006337559],"study_design_scores_gemma":[0.00002986805,0.0004586919,0.7712713,0.00001349045,0.0001512483,0.00544487,0.0001167243,0.00211739,0.2169499,0.0002200387,0.003209544,0.00001682927],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977043,0.0006301383,0.000850892,0.00002254333,0.000004704071,0.000007856791,0.0003903045,0.00007872642,0.0003104443],"genre_scores_gemma":[0.998704,0.0002331393,0.0003509272,0.00001060678,0.000004339544,0.000007712429,0.0004235637,0.000009609446,0.0002562308],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001633494,"threshold_uncertainty_score":0.005464613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003446415097881541,"score_gpt":0.2032817324002883,"score_spread":0.1998353173024067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}