{"id":"W2939620966","doi":"10.2298/abs190404027t","title":"Enrichment of Cxcl12 promoter with TET2: A possible link between promoter demethylation and enhanced gene expression in the absence of PARP-1","year":2019,"lang":"en","type":"article","venue":"Archives of Biological Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja; Alexander von Humboldt-Stiftung","keywords":"Biology; Promoter; DNA demethylation; Molecular biology; Poly ADP ribose polymerase; DNA methylation; Gene expression; Demethylation; CpG site; Gene; Regulation of gene expression; Transcription (linguistics); Cell biology; Genetics; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003921497,0.00006731393,0.000127711,0.00003478589,0.00002523928,0.000004813665,0.0001756258,0.00004963294,0.000003419943],"category_scores_gemma":[0.00004476597,0.00003265677,0.00002536758,0.0001027639,0.0003676166,0.000004901946,0.00007385068,0.00003652582,1.374182e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":8.163556e-7,"about_ca_system_score_gemma":0.00001985609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000129356,"about_ca_topic_score_gemma":0.000003825546,"domain_scores_codex":[0.9992311,0.000122166,0.0002010361,0.0002189225,0.0001201757,0.0001065957],"domain_scores_gemma":[0.9995773,0.0001075527,0.0001556322,0.0001213372,0.00001949839,0.00001870621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002703315,0.0000203353,0.2447691,0.00001129463,0.000002969507,4.214009e-8,0.0002348019,0.00002946769,0.7455003,0.00002200331,5.901119e-8,0.009382541],"study_design_scores_gemma":[0.0001133839,0.001016518,0.3575233,0.00002692697,0.000001494917,1.394133e-7,0.00004211335,0.0000330026,0.6397569,0.001439334,0.00001163537,0.00003520094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952093,0.0004570574,0.003488172,0.00007202308,0.000009775693,0.0002561275,0.000005116636,0.00000100078,0.0005014699],"genre_scores_gemma":[0.9897448,0.0002403585,0.009962372,0.00000604197,0.00001846199,0.000006561972,0.0000100572,0.00000146908,0.000009901465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1127542,"threshold_uncertainty_score":0.1354499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02128659322566102,"score_gpt":0.2755152631365836,"score_spread":0.2542286699109226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}