{"id":"W2939630748","doi":"10.1021/acsnano.8b07662","title":"Polysaccharide Nanoparticles Can Efficiently Modulate the Immune Response against an HIV Peptide Antigen","year":2019,"lang":"en","type":"article","venue":"ACS Nano","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"National Institutes of Health; Horizon 2020 Framework Programme; Ministerio de Educación, Cultura y Deporte; National Institute of Allergy and Infectious Diseases; European Commission","keywords":"Immunogenicity; Antigen; Peptide; Chemistry; Immune system; Polyglutamic acid; Chitosan; Nanoparticle; Biophysics; Conjugated system; Polysaccharide; Biochemistry; Biology; Materials science; Nanotechnology; Immunology; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001326327,0.000344618,0.0001304879,0.0001279214,0.00004966199,0.0001869837,0.0001150602,0.0002837508,0.0004613373],"category_scores_gemma":[0.0001156942,0.00009760597,0.0001732152,0.00006724328,0.0001260779,0.0001276127,0.0001429119,0.0002826548,0.0001492912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001589516,"about_ca_system_score_gemma":0.0001025526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002153802,"about_ca_topic_score_gemma":0.0003532991,"domain_scores_codex":[0.9999216,0.00001615992,0.000005769409,0.00001447646,0.00002126999,0.00002083493],"domain_scores_gemma":[0.9999535,0.0000117218,0.00001478308,0.000003849794,0.00000634487,0.000009861761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003704331,0.00001557464,0.00002826555,0.00002552781,0.000003188815,0.00001185871,0.00000405373,0.00009195504,0.9985759,0.00004536053,0.00001327646,0.001147909],"study_design_scores_gemma":[0.00001707358,0.0004906228,0.0006288398,0.000003586008,0.0000150801,0.00003720559,0.000003970235,0.001071617,0.996615,0.00003481884,0.001079313,0.000002868147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990616,0.001749246,0.006016861,0.00007122119,0.00005354817,0.00005525778,0.00005392155,0.00006635836,0.001317517],"genre_scores_gemma":[0.9938225,0.0006675635,0.004308852,0.00005986485,0.00001667252,0.00002818989,0.00007270944,0.00001265927,0.001010968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004613373,"threshold_uncertainty_score":0.001543343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128065584537829,"score_gpt":0.2455514966878505,"score_spread":0.2342708408424722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}