{"id":"W2939630748","doi":"10.1021/acsnano.8b07662","title":"Polysaccharide Nanoparticles Can Efficiently Modulate the Immune Response against an HIV Peptide Antigen","year":2019,"lang":"en","type":"article","venue":"ACS Nano","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Manitoba","funders":"National Institutes of Health; Horizon 2020 Framework Programme; Ministerio de Educación, Cultura y Deporte; National Institute of Allergy and Infectious Diseases; European Commission","keywords":"Immunogenicity; Antigen; Peptide; Chemistry; Immune system; Polyglutamic acid; Chitosan; Nanoparticle; Biophysics; Conjugated system; Polysaccharide; Biochemistry; Biology; Materials science; Nanotechnology; Immunology; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000598949,0.0001865817,0.0002212419,0.00009359584,0.0003486147,0.00004288381,0.0004472781,0.0001146897,0.0003090888],"category_scores_gemma":[0.00008793092,0.0001197676,0.00008778437,0.0001925104,0.0001922054,0.00009050341,0.0001441753,0.0002071265,0.007885193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006311685,"about_ca_system_score_gemma":0.0001446537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002866561,"about_ca_topic_score_gemma":0.00005495398,"domain_scores_codex":[0.9981202,0.0005688242,0.0002405261,0.0003458779,0.00007773883,0.0006468337],"domain_scores_gemma":[0.9987885,0.0002256128,0.00007089875,0.0008003631,0.00006003193,0.00005459387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008883473,0.0001887485,0.007406227,0.000003053885,0.0001514907,0.00002352462,0.0008707641,0.00005142399,0.9876361,0.0001221281,0.0005700139,0.002088152],"study_design_scores_gemma":[0.00180752,0.0005137423,0.1014986,0.00001989671,0.00001922691,0.00003121306,0.0004488946,0.00001562432,0.8810084,0.00003123184,0.01442115,0.0001845508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995423,0.00151047,0.000002137586,0.001853148,0.0002392413,0.0004565161,0.0001175315,0.00007766111,0.0003203375],"genre_scores_gemma":[0.98793,0.00008496444,0.00001718268,0.000212618,0.00001431408,0.0000291417,0.0001237664,0.00002268821,0.01156535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1066277,"threshold_uncertainty_score":0.9928873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128065584537829,"score_gpt":0.2455514966878505,"score_spread":0.2342708408424722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}