{"id":"W2939773590","doi":"10.1016/j.celrep.2019.03.061","title":"A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"European Regional Development Fund; Horizon 2020 Framework Programme; French Infrastructure for Integrated Structural Biology; National Institutes of Health; Medical Research Council; Sapienza Università di Roma; National Cancer Institute; Ministero dell’Istruzione, dell’Università e della Ricerca; European Synchrotron Radiation Facility; European Molecular Biology Organization; Nanyang Technological University; Direction Régionale de l'Alimentation, de l'Agriculture et de la Forêt de la région Auvergne-Rhône-Alpes; Infrastructures en Biologie Santé et Agronomie; Agence Nationale de la Recherche; Wellcome Trust; Associazione Italiana per la Ricerca sul Cancro","keywords":"Nucleosome; Linker DNA; Chromatin; Demethylase; Histone H3; Histone; Biology; Cell biology; Histone code; Chromatosome; Histone methylation; Transcription (linguistics); Biochemistry; Biophysics; DNA; Chemistry; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399316,0.0001472768,0.0001127564,0.00007495372,0.0001673504,0.0002043782,0.0001958505,0.0001683865,0.0008302851],"category_scores_gemma":[0.0001151471,0.0001438887,0.0001352863,0.00004754733,0.0002211853,0.000217715,0.0002594707,0.0002675749,0.0002633184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003349846,"about_ca_system_score_gemma":0.0001994866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000405153,"about_ca_topic_score_gemma":0.0007410747,"domain_scores_codex":[0.9999412,0.000006199057,0.000003749455,0.00002364345,0.00001329122,0.00001191884],"domain_scores_gemma":[0.9999418,0.000008470235,0.00001196971,0.00001366585,0.000006350899,0.00001782105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004494458,0.000005922574,0.0004787226,0.00001702967,0.000004654316,0.00002877194,0.00001162824,0.0001053404,0.9984659,0.0001768202,0.00002682827,0.0006333927],"study_design_scores_gemma":[0.000009278806,0.00003390148,0.001965818,0.000001496844,0.000003779248,0.0001340965,0.00001710185,0.002769149,0.9940501,0.00007577147,0.000935716,0.000003725599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947379,0.0002230044,0.004276719,0.00005147183,0.000007582595,0.000006374635,0.00007040453,0.00005633212,0.0005702814],"genre_scores_gemma":[0.9977924,0.00005107516,0.001434257,0.0000131124,0.000001222824,0.000003957625,0.00007091863,0.000006888443,0.0006261923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008302851,"threshold_uncertainty_score":0.002777576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009280024187450296,"score_gpt":0.2342304150388894,"score_spread":0.2249503908514391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}