{"id":"W2939773590","doi":"10.1016/j.celrep.2019.03.061","title":"A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"European Regional Development Fund; Horizon 2020 Framework Programme; French Infrastructure for Integrated Structural Biology; National Institutes of Health; Medical Research Council; Sapienza Università di Roma; National Cancer Institute; Ministero dell’Istruzione, dell’Università e della Ricerca; European Synchrotron Radiation Facility; European Molecular Biology Organization; Nanyang Technological University; Direction Régionale de l'Alimentation, de l'Agriculture et de la Forêt de la région Auvergne-Rhône-Alpes; Infrastructures en Biologie Santé et Agronomie; Agence Nationale de la Recherche; Wellcome Trust; Associazione Italiana per la Ricerca sul Cancro","keywords":"Nucleosome; Linker DNA; Chromatin; Demethylase; Histone H3; Histone; Biology; Cell biology; Histone code; Chromatosome; Histone methylation; Transcription (linguistics); Biochemistry; Biophysics; DNA; Chemistry; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002974787,0.0001572314,0.0001335471,0.00002969369,0.0001006982,0.00003451808,0.0001088373,0.0001371167,0.0001170772],"category_scores_gemma":[0.00004679777,0.0001254604,0.00009382013,0.00008946764,0.00004319685,0.000003798335,0.00005469131,0.00007818338,0.00004089783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001245034,"about_ca_system_score_gemma":0.00005334728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002307822,"about_ca_topic_score_gemma":0.000004981921,"domain_scores_codex":[0.998829,0.00008259756,0.0002950585,0.000391375,0.0001939216,0.0002080619],"domain_scores_gemma":[0.9989808,0.00002597227,0.0002711653,0.0005708869,0.00008594349,0.00006518931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009896383,0.00004590071,0.005821272,0.00001156515,0.00001288108,0.000003942986,0.00002719524,0.0004164012,0.9919431,0.00001625479,0.00062037,0.001071231],"study_design_scores_gemma":[0.0002730482,0.0001633243,0.004726199,0.000004542043,0.00002030509,0.000004569325,0.00003347194,0.001951294,0.9245895,0.0004540153,0.06757885,0.0002009319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852895,0.001035873,0.009304306,0.000119706,0.0002796942,0.0004008205,0.000006775275,0.00001970352,0.003543685],"genre_scores_gemma":[0.9956902,0.00006249003,0.001567855,0.0002054886,0.00007925806,0.00001831968,0.0004436648,0.00003095961,0.001901782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06735364,"threshold_uncertainty_score":0.5116127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009280024187450296,"score_gpt":0.2342304150388894,"score_spread":0.2249503908514391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}