{"id":"W2939791458","doi":"10.1186/s12985-019-1134-8","title":"Noncovalent SUMO-interaction motifs in HIV integrase play important roles in SUMOylation, cofactor binding, and virus replication","year":2019,"lang":"en","type":"article","venue":"Virology Journal","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; University of St Andrews; Manitoba Health Research Council","keywords":"SUMO protein; Integrase; Biology; Viral replication; Cell biology; Transcription factor; Ku70; Ubiquitin; Genetics; Virus; DNA; Gene; DNA repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006288816,0.0001290229,0.0001588101,0.0001893262,0.00004443827,0.0000271126,0.0001040744,0.0001955731,0.0001357609],"category_scores_gemma":[0.0001050398,0.0001174262,0.00004330408,0.00007147215,0.00003898589,0.00001597337,0.00004700318,0.0003429578,0.00002982024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005438792,"about_ca_system_score_gemma":0.00006268985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003263164,"about_ca_topic_score_gemma":0.0003904215,"domain_scores_codex":[0.998852,0.0001382599,0.0004009512,0.0003139728,0.00008055672,0.0002143084],"domain_scores_gemma":[0.9994218,0.00002204525,0.000230239,0.0002175744,0.00003774132,0.00007062606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001836485,0.00005341581,0.3612458,0.00000462763,0.00001267101,0.00001112631,0.0001204797,0.00003505251,0.6374559,0.00002821997,0.0001278758,0.0007211113],"study_design_scores_gemma":[0.002955745,0.0008911474,0.4135418,0.00008309358,0.00001898584,0.0009170764,0.0003655395,0.001332225,0.5654502,0.0003854536,0.01368992,0.0003688604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983557,0.0004898316,0.0002157807,0.0003193175,0.0001819152,0.0001942788,0.00001822941,0.000005206542,0.0002197768],"genre_scores_gemma":[0.9985682,0.0007664631,0.0001404825,0.0001518232,0.0001063693,0.00001284423,0.00007782238,0.00001387827,0.0001620927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07200576,"threshold_uncertainty_score":0.4788503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01025167053041504,"score_gpt":0.2617318139760083,"score_spread":0.2514801434455932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}