{"id":"W2939906752","doi":"10.1158/1078-0432.ccr-17-0375","title":"High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Optometric Education Trust Fund; Dalhousie University; Izaak Walton Killam Health Centre","funders":"National Cancer Institute; Pediatric Cancer Research Foundation","keywords":"Sarcoma; Ewing's sarcoma; Cancer research; Medicine; Focal adhesion; Aurora inhibitor; Aurora kinase; Kinase; Malignancy; Aurora B kinase; Cell growth; Internal medicine; Pathology; Cell; Biology; Cancer; Cell cycle; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003552669,0.0007196646,0.0008583193,0.001057776,0.0003240671,0.0004758112,0.0003812476,0.0003297252,0.002390551],"category_scores_gemma":[0.00023282,0.0003177068,0.0005782555,0.0006349289,0.000215664,0.0002472388,0.000372729,0.0005245634,0.0004246319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004239632,"about_ca_system_score_gemma":0.000600433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007302476,"about_ca_topic_score_gemma":0.003146639,"domain_scores_codex":[0.9997298,0.00005434819,0.00002250614,0.00004962669,0.0001004721,0.00004321126],"domain_scores_gemma":[0.9998748,0.00002933104,0.00002588026,0.00001092715,0.00002576365,0.00003329759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006306842,0.001451661,0.001681008,0.0003763645,0.0001829674,0.0002244309,0.00002545687,0.002806752,0.970512,0.0001640927,0.0006885304,0.0212561],"study_design_scores_gemma":[0.001104618,0.02094228,0.01389875,0.00005909939,0.0008621498,0.001305225,0.00008526423,0.008689888,0.9428356,0.0001743605,0.009995172,0.00004755228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807468,0.006114108,0.00461361,0.0003496168,0.00005431938,0.0007983335,0.002000059,0.0002757001,0.005047325],"genre_scores_gemma":[0.9856278,0.003986935,0.005799767,0.0001611706,0.00002516599,0.0002235917,0.001886065,0.0000208521,0.002268608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002390551,"threshold_uncertainty_score":0.007997215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07070187374029319,"score_gpt":0.4188239804210002,"score_spread":0.348122106680707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}