{"id":"W2940158264","doi":"10.1021/acs.joc.8b03073","title":"Chiral Brønsted Acid-Catalyzed Metal-Free Asymmetric Direct Reductive Amination Using 1-Hydrosilatrane","year":2019,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Northern Illinois University","keywords":"Reductive amination; Chemistry; Brønsted–Lowry acid–base theory; Catalysis; Reagent; Organic chemistry; Hydride; Enantiomer; Enantiomeric excess; Hydrosilylation; Amination; Silane; Combinatorial chemistry; Enantioselective synthesis; Metal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008237142,0.0002842245,0.0005224912,0.0001786501,0.0001341153,0.00004833916,0.001024649,0.0002033392,0.003859648],"category_scores_gemma":[0.0008868368,0.0002154754,0.0003263538,0.001699487,0.00009490037,0.0002777981,0.0001535848,0.0005860736,0.00004586896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004262347,"about_ca_system_score_gemma":0.0002065124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008634907,"about_ca_topic_score_gemma":6.825841e-7,"domain_scores_codex":[0.9978157,0.00005064301,0.000749274,0.0002343307,0.0008410878,0.000309013],"domain_scores_gemma":[0.9972156,0.0001891513,0.001329226,0.0007676894,0.0003421385,0.0001561442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008273586,0.0001142651,0.0001846093,0.00007762365,0.0004535194,0.000009102838,0.0002802691,0.00008594393,0.9970189,0.000002524381,0.00009255243,0.001597904],"study_design_scores_gemma":[0.00153401,0.00001568858,0.00008296663,0.00005206618,0.0006870258,0.0007140485,0.0007745558,0.0006928057,0.9948904,0.00006913851,0.0002375001,0.0002497906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735907,0.00156647,0.0003743708,0.0001722906,0.0001548475,0.00006537462,0.00002244565,0.00004037848,0.02401315],"genre_scores_gemma":[0.9962443,0.0001128418,0.0001934305,0.00002630304,0.0003474939,7.977995e-7,0.00003025952,0.00005040437,0.002994204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0226536,"threshold_uncertainty_score":0.9970509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008767067062618891,"score_gpt":0.2230611976290995,"score_spread":0.2142941305664806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}