{"id":"W2940261233","doi":"10.1172/jci.insight.127113","title":"Identification of rare HIV-1–infected patients with extreme CD4+ T cell decline despite ART-mediated viral suppression","year":2019,"lang":"en","type":"article","venue":"JCI Insight","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Winnipeg Regional Health Authority; Children's Hospital of Eastern Ontario","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; U.S. Department of Health and Human Services","keywords":"Antiretroviral therapy; Viral load; Human immunodeficiency virus (HIV); Viral replication; Immune system; Cd4 t cell; Immunology; Virology; T cell; Medicine; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001802834,0.000303814,0.0003595926,0.000499721,0.0004451683,0.0006574308,0.0002717364,0.0003931678,0.001596104],"category_scores_gemma":[0.0008438488,0.0001207259,0.0001882996,0.0003419851,0.0002869085,0.0002859762,0.0003665178,0.0003651247,0.0002640485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001349104,"about_ca_system_score_gemma":0.0001066172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002771179,"about_ca_topic_score_gemma":0.0003084225,"domain_scores_codex":[0.9998168,0.00002938377,0.00002323576,0.00005956324,0.0000242911,0.00004673683],"domain_scores_gemma":[0.9996197,0.0000883365,0.0001161405,0.00003633734,0.00003438428,0.0001049856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001067689,0.0001354689,0.9568267,0.00004675968,0.00003141,0.01699036,0.0004692893,0.00009852357,0.01219333,0.0001543008,0.0003296768,0.01165653],"study_design_scores_gemma":[0.0000423897,0.0009695241,0.8991652,0.00002758472,0.00006985589,0.09290997,0.001006992,0.0008528063,0.003044013,0.0003046013,0.00158626,0.0000206649],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991374,0.0001407057,0.0001455077,0.00002441929,0.000003905152,0.000009050876,0.00005349802,0.000008494261,0.0004768947],"genre_scores_gemma":[0.9996316,0.00004114779,0.0001103451,0.00002697537,0.00001195729,0.000004045527,0.00008688477,0.000002550349,0.0000844524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001596104,"threshold_uncertainty_score":0.005339444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008836042315211429,"score_gpt":0.2179650358774471,"score_spread":0.2091289935622356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}