{"id":"W2940266479","doi":"10.1016/j.vaccine.2019.04.035","title":"An in vitro functional assay to measure the biological activity of TB vaccine candidate H4-IC31","year":2019,"lang":"en","type":"article","venue":"Vaccine","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Sanofi Pasteur; University of Central Florida","keywords":"Potency; Peripheral blood mononuclear cell; In vitro toxicology; Immune system; Immunology; Cytokine; In vitro; Biology; Pharmacology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000623066,0.0001739522,0.0002601864,0.00006438046,0.00004377881,0.00001728189,0.000282561,0.0001385564,0.0000898118],"category_scores_gemma":[0.00007885601,0.0001077183,0.00007940354,0.0001996381,0.000004138303,0.00001174012,0.0001350465,0.000141231,0.00002338464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000016747,"about_ca_system_score_gemma":0.00005120788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008795282,"about_ca_topic_score_gemma":0.00006850597,"domain_scores_codex":[0.998996,0.0001006846,0.0002765405,0.0002560222,0.0001275814,0.0002431988],"domain_scores_gemma":[0.9991668,0.00002381499,0.0001069962,0.0005488573,0.00008812657,0.00006535146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001182404,0.0001208435,0.02259675,0.00001334863,0.00004016552,3.100913e-7,0.00004557012,0.0003050853,0.9717416,0.00002825485,0.0007816861,0.003143991],"study_design_scores_gemma":[0.001940114,0.0007247872,0.3401602,0.00001301335,0.0000141063,0.00001488958,0.0001415194,0.001238357,0.6500602,0.00002881319,0.005424954,0.0002389985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974709,0.0001988937,0.0007986347,0.0006570139,0.0001356122,0.0003760846,0.00002774819,0.000008532671,0.0003265461],"genre_scores_gemma":[0.9989715,0.00004203254,0.0002477618,0.0003080898,0.0001159476,0.00002422479,0.0001565818,0.00001375113,0.0001201127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3216814,"threshold_uncertainty_score":0.4392627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0166977905979865,"score_gpt":0.2329389582661675,"score_spread":0.216241167668181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}