{"id":"W2940266479","doi":"10.1016/j.vaccine.2019.04.035","title":"An in vitro functional assay to measure the biological activity of TB vaccine candidate H4-IC31","year":2019,"lang":"en","type":"article","venue":"Vaccine","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sanofi (Canada)","funders":"Sanofi Pasteur; University of Central Florida","keywords":"Potency; Peripheral blood mononuclear cell; In vitro toxicology; Immune system; Immunology; Cytokine; In vitro; Biology; Pharmacology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001841617,0.001547858,0.000698463,0.0006187562,0.0003462787,0.0007612609,0.0004860909,0.00104528,0.003455796],"category_scores_gemma":[0.00108133,0.0003347822,0.0008616881,0.0005764351,0.0004466873,0.0005008065,0.0004246947,0.001819114,0.002213299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003180074,"about_ca_system_score_gemma":0.0004404752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003722514,"about_ca_topic_score_gemma":0.0005099975,"domain_scores_codex":[0.9978743,0.0007922692,0.0002335718,0.0002308207,0.0006931284,0.0001758413],"domain_scores_gemma":[0.9985518,0.000557925,0.0002112003,0.0002320113,0.0003615147,0.00008553046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009524385,0.0001421215,0.0005410674,0.0001386074,0.00001022844,0.00002447955,0.00003080574,0.000156645,0.9970284,0.00006554159,0.0001037839,0.001663063],"study_design_scores_gemma":[0.00001637361,0.001698082,0.001994229,0.00002353684,0.00002971295,0.0001292289,0.00003793077,0.0006442788,0.9933909,0.00004547289,0.001981105,0.000009078521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8651114,0.005284094,0.1028339,0.000447404,0.0005615381,0.001839053,0.00615211,0.0007249296,0.01704551],"genre_scores_gemma":[0.8773862,0.004611495,0.08777247,0.0005387209,0.0003046779,0.002115855,0.01020835,0.000149464,0.0169127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003455796,"threshold_uncertainty_score":0.01156074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0166977905979865,"score_gpt":0.2329389582661675,"score_spread":0.216241167668181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}