{"id":"W2940408530","doi":"10.1186/s12885-019-5449-z","title":"Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors","year":2019,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Norges Forskningsråd; Universitetet i Bergen; L. Meltzers Høyskolefond; University of Toronto","keywords":"Integrin; Stromal cell; Tumor microenvironment; Collagen receptor; Chemistry; Pathology; Extracellular matrix; Cancer research; Stroma; Triple-negative breast cancer; Tumor progression; Breast cancer; Cancer; Medicine; Internal medicine; Immunohistochemistry; Cell; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001406977,0.0002325812,0.0004046941,0.0002591323,0.00004892147,0.00005040932,0.0001856075,0.0001376457,0.002890118],"category_scores_gemma":[0.000148241,0.000184467,0.00007519779,0.0004103046,0.0001819122,0.0001100377,0.0001657145,0.0002905089,0.00002189568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001743819,"about_ca_system_score_gemma":0.0005450629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001430198,"about_ca_topic_score_gemma":0.001259718,"domain_scores_codex":[0.9981371,0.0001163447,0.0002912967,0.0005366388,0.0004969157,0.0004216701],"domain_scores_gemma":[0.9992141,0.0001002511,0.0000726647,0.000276933,0.0001426904,0.000193343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007946671,0.0003136469,0.2437329,0.001237652,0.000174892,0.0001823439,0.007147667,0.0003306504,0.7207333,0.0002021673,0.007664992,0.01033305],"study_design_scores_gemma":[0.01050486,0.001529308,0.9011237,0.001362815,0.0001804364,0.0004704196,0.006857315,0.005542379,0.06807456,0.0001060979,0.00350964,0.0007384532],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993924,0.002394939,0.00001141233,0.0003299549,0.0002430325,0.001083151,0.0001956241,0.00003090161,0.001786972],"genre_scores_gemma":[0.9928213,0.00007678939,0.0003018331,0.00008722426,0.000174446,0.00004904613,0.00001895724,0.000033527,0.006436924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6573908,"threshold_uncertainty_score":0.9980214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326956596794051,"score_gpt":0.2942106525382399,"score_spread":0.2809410865702994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}